The Human Parvovirus
Since parvoviruses have come to our attention almost 25 years ago, repeated attempts have been made to relate these agents to specific human disease. H-1, HT, HB, H-3, TVX, and Lu III viruses have thus on occasion been thought to represent candidates for the role of a genuine human parvovirus. In most instances, however, such conclusions had to be put aside because of rapidly evolving contradictory evidence and in a few cases (e.g., H-1 and HB viruses), the true role of the virus in human infections is still under dispute (cf. Chapter 8). Several candidate viruses, however, were unquestionably recovered from human clinical specimens. Among them are the parvovirus-like particles identified by Paver et al. (1973) in human feces, by Cossart et al. (1975) in sera of asymptomatic blood donors and, more recently, by Schneerson et al. (1980) in sera of patients suffering from febrile illness. In contrast to the agents first listed, the virus-like particles resisted progagation in vitro. They could only be detected by either counter immuno-electrophoresis (CIE) or immune electron microscopy (IEM), and their tentative classification as parvoviruses was based on morphologic and physical parameters (i.e., isometric, probably icosahedral particles with a diameter of 20–25 nm which banded at a buoyant density of 1.36–1.40 g/ml in CsCl). Serologic surveys conducted by CIE and IEM also revealed that infections with these particles were rather common. Nevertheless, it proved difficult to link particles and infections to a specific clinical syndrome.
KeywordsSickle Cell Anaemia Hereditary Spherocytosis Immune Electron Microscopy Aplastic Crisis Human Clinical Specimen
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