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Adeno-Associated Virus DNA Structure and Replication

  • Kenneth I. Berns
  • William W. Hauswirth
Part of the The Viruses book series (VIRS)

Abstract

The primary structure of adeno-associated virus (AAV) DNA has been pivotal in understanding its replication. The nucleotide sequence arrangement in virion DNA and the structure of replicative forms have suggested rather directly an experimentally verifiable model for replication. Thus, as each detail of genome structure became known, the mechanism of replication became better defined. For this reason we have chosen to describe experiments leading to our present ideas of AAV DNA structure and replication in more or less historical order.

Keywords

Terminal Sequence Inverted Terminal Repetition Helper Virus Replicative Intermediate Defective Genome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Kenneth I. Berns
    • 1
  • William W. Hauswirth
    • 1
  1. 1.Department of Immunology and Medical MicrobiologyCollege of Medicine, University of FloridaGainesvilleUSA

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