Systolic Time Intervals in Coronary Artery Disease
It is well over a century since A. H. Garrod noted that the duration of left ventricular ejection in man bears an inverse relationship to heart rate. Indeed, the measurement of the duration of systole, the first method applied in the evaluation of left ventricular function in humans preceded by at least two decades the inventions of the sphygmomanometer, the electrocardiogram and the chest roentgenogram. Despite their early introduction, clinical use of the systolic time intervals (STI) has lagged appreciably with respect to the more commonly applied clinical measures of stroke and minute output of the heart, ventricular diastolic and systolic pressure, and ejection fraction. Among these measures of left ventricular performance, the STI remain unique in that they offer insight into the timing of the left ventricular contraction cycle, a dimension which is not encompassed in other measures.
KeywordsLeft Ventricular Dysfunction Previous Myocardial Infarction Constrictive Pericarditis Left Ventricular Performance Systolic Time Interval
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