Evaluation of Left Ventricular Function in Chronic Regurgitation Before and After Valve Replacement

  • M. G. Modena
  • A. Benassi
  • G. Mattioli
Part of the Ettore Majorana International Science Series book series (volume 21)


Controversy continues regarding the appropriate timing of operative intervention in patients with chronic aortic regurgitation (CAR) [1,2,3,4]. Once symptoms develop, surgical replacement of the aortic valve is recommended because continued medical therapy is associated with progressive clinical deterioration. However, if surgery is delayed until the occurrence of symptoms and marked cardiomegaly, some patients have left ventricular dysfunction and do not improve symptomatically postoperatively.


Aortic Valve Left Ventricular Function Aortic Valve Replacement Wall Stress NYHA Class 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    W. L. Henry, R. O. Bonow, J. S. Borer, J. H. Ware, K. M. Kent, D. R. Redwood, C. L. McIntosh, A. G. Morrow, and S. E. Epstein, Observations on the optimum time for operative intervention for aortic regurgitation, Circulation, 61: 471 (1980).CrossRefGoogle Scholar
  2. 2.
    R. O. Bonow, D. R. Rosing, and C. L. McIntoshs, The natural history of a symptomatic patients with aortic regurgitation and normal left ventricular function, Circulation, 68: 509 (1983).CrossRefGoogle Scholar
  3. 3.
    R. 0. Bonow, D. R. Rosing, K. M. Kent, and S. E. Epstein, Timing of operation for chronic aortic regurgitation, Am.J.Cardiol., 68: 509 (1983).Google Scholar
  4. 4.
    J. Ross, Left ventricular function and the timing of surgical treatment in valvular heart disease, Am.Int.Med., 94: 498 (1981).Google Scholar
  5. 5.
    W. H. Gaasch, C. W. Andrias, and H. J. Levine, Chronic aortic regurgitation: the effect of aortic valve replacement on left ventricular volume, mass and function, Circulation, 58: 825 (1978).CrossRefGoogle Scholar
  6. 6.
    A. G. Kumpuris, M. A. Quinones, A. D. Waggoner, D. J. Kanon, J. G. Nelson, and R. R. Miller, Importance of preoperative hypertrophy, wall stress and end-systolic dimension as echo-cardiographic predictors of normalization of left ventricular dilatation after valve replacement in chronic aortic insufficiency, Am.J.Cardiol., 49: 1091 (1982).CrossRefGoogle Scholar
  7. 7.
    M. Osbakken, A. A. Bove, and J. F. Spann, Left ventricular function in chronic aortic regurgitation with reference to end-systolic pressure, volume and stress relations, Am.J.Cardiol., 47: 193 (1981).CrossRefGoogle Scholar
  8. 8.
    R. L. Popp, K. Filly, 0. R. Brown, and D. C. Harrison, Effect of transducer placement on echocardiographic left ventricular dimensions, Am.J.Cardiol., 35:537 (3975).Google Scholar
  9. 9.
    J. D. Marsh, L. H. Green, J. Wynne, P. F. Chon, and W. Grossman, Left ventricular end-systolic pressure-dimension and stress length relations in normal human subjects, Am.J.Cardiol., 44: 1311 (1977).CrossRefGoogle Scholar
  10. 10.
    W. Grossman, D. Jones, and L. P. McLaurin, Wall stress and patterns of hypertrophy in the human left ventricle, J.Clin. Invest., 56: 56 (1975).CrossRefGoogle Scholar
  11. 11.
    K. W. Borow, L. H. Green, W. Grossman, and E. Braunwald, Left ventricular end-systolic stress-shortening and stress-length relations in humans, Am.J.Cardiol., 50: 1301 (1982).CrossRefGoogle Scholar
  12. 12.
    G. W. Burggraf and E. Graige, Echocardiographic studies on left ventricular wall motion and dimensions after valvular heart surgery, Am.J.Cardiol., 35: 473 (1975).CrossRefGoogle Scholar
  13. 13.
    A. M. Abdulla, M. J. Frank, M. I. Canedo, and M. A. Stefadouros, Limitations of echocardiography in the assessment of left ventricular size and function in aortic regurgitation, Circulation, 61: 148 (1980).CrossRefGoogle Scholar
  14. 14.
    A. D. Johnson, J. S. Alper, G. S. Frances, V. R. Vieweg, I. OcKone, and A. D. Hagan, Assessment of left ventricular function in severe aortic regurgitation, Circulation, 54: 975 (1976).CrossRefGoogle Scholar
  15. 15.
    M. A. Quinones, E. Pickering, and J. K. Alexander, Percentage of shortening of the echocardiographic left ventricularGoogle Scholar
  16. dimension: its use in determining ejection fraction and stroke volume, Chest, 74:50 (1978).Google Scholar
  17. 16.
    M. A. Quinones, W. H. Gaasch, J. S. Cole, and J. R. Alexander, Echocardiographic determination of left ventricular stress-velocity relations in man: with reference to the effects of loading and contractility, Circulation, 51: 689 (1975).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • M. G. Modena
    • 1
  • A. Benassi
    • 1
  • G. Mattioli
    • 1
  1. 1.Cattedra di Malattie CardiovascolariUniversitè di ModenaModenaItaly

Personalised recommendations