Non-Invasive Assessment of LV Systolic Function and Diastolic Filling at Rest and During Exercise in Coronary Heart Disease

  • P. Assennato
  • B. Candela
  • E. Hoffmann
  • G. Indovina
  • L. Messina
  • A. Raineri
Part of the Ettore Majorana International Science Series book series (volume 21)


In the assessment of the main determinants of cardiac function the study of the systolic phase and diastolic filling appear to be of paramount importance[1–3].


Left Ventricular Ejection Fraction Diastolic Function Left Ventricular Volume Left Ventricular Systolic Function Filling Rate 
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  1. 1.
    J. S. Borer, S. C. Bacharach, M. V. Green, K. M. Kent, S. E. Epstein, and G. S. Johnston, Real-time radionuclide cineangiography in the non-invasive evaluation of global and regional left ventricular function at rest and during exercise in patients with coronary artery disease, N.Engl.J.Med., 296: 839 (1977).CrossRefGoogle Scholar
  2. 2.
    H. J. Berger, C. A. Reduto, D. E. Johnstone, H. Borkowski, J. M. Sands, P. F. Cohen, R. A. Langow, A. Gottschalk, and B. L. Zaret, Global and regional left ventricular response to exercise in coronary artery disease: assessment by quantitative radionuclide angiocardiography, Am.J.Med., 66: 13 (1979).CrossRefGoogle Scholar
  3. 3.
    J. W. Covell, J. Ross, Jr., Nature and significance of alterations in myocardiol compliance, Am.J.Cardiol., 32: 455 (1979).Google Scholar
  4. 4.
    H. N. Wagner, The use of the nuclear stethoscope for temporal imaging of left ventricular function, in: “Nuclear Cardiology,” selected computer aspects, p. 45, Bachards, New York (1978).Google Scholar
  5. 5.
    D. G. Pavel, A. M. Zimmer, and V. N. Peterson, In vivo labeling of red blood cells with Tc 99m, a new approach to blood pool visualization, J.Nucl.Med., 18:305 (1977).Google Scholar
  6. 6.
    N. H. Wagner, P. Rigo, R. H. Baxter, P. O. Alderson, K. H. Douglas, and D. F. Housholder, Monitoring ventricular function at rest and during exercise with a non-imaging nuclear detector, Am.J.Cardiol., 43: 975 (1979).CrossRefGoogle Scholar
  7. 7.
    S. L. Bacharach, M. V. Green, and J. S. Borer, A realtime system for multi-image gated cardiac studies, J.Nucl.Med., 18: 79 (1977).Google Scholar
  8. 8.
    M. V. Green, W. Brody, M. A. Douglas, J. S. Borer, H. G. Ostrow, B. R. Line, S. L. Bacharach, and G. S. Johnson, Ejection fraction by count rate from gated images, J.Nucl.Med., 19: 880 (1978).Google Scholar
  9. 9.
    S. L. Bacharach, M. V. Green, J. S. Borer, J. E. Hyde, S. P. Farkas, and G. S. Johnston, Left-ventricular peak ejection rate, filling rate and ejection fraction-frame rate requirements at rest and exercise: concise communication, J.Nucl.Med., 20: 189 (1979).Google Scholar
  10. 10.
    K. E. Hammermeister and J. R. Warbasse, The rate of change of left ventricular volume in man: diastolic events in health and disease, Circulation, 49: 739 (1974).CrossRefGoogle Scholar
  11. 11.
    K. E. Hammermeister, R. C. Brooks, and J. R. Warbasse, The rate of change of left ventricular volume in man: validation and peak systolic ejection rate in health and disease, Circulation, 49: 729 (1977).CrossRefGoogle Scholar
  12. 12.
    D. G. Gibson, T. A. Prewitt, and D. J. Brown, Analysis of left ventricular wall movement during isovolumic relaxation and its relation to coronary artery disease, Br.Heart J., 38: 1010 (1976).CrossRefGoogle Scholar
  13. 13.
    W. Grossman and L. P. McLaurin, Diastolic properties of the left ventricle, Ann.Intern.Med., 84: 316 (1976).Google Scholar
  14. 14.
    G. Diamond and J. S. Forrester, Effect of coronary artery disease and acute myocardial infarction on left ventricular compliance in man, Circulation, 45: 11 (1972).CrossRefGoogle Scholar
  15. 15.
    J. Mirsky, P. F. Cohen, J. A. Levine, R. Gorlin, A. V. Herman, T. H. Krenlen, and E. H. Sonnenblick, Assessment of left ventricular stiffness in primary myocardial disease and coronary artery disease, Circulation, 50: 158 (1976).Google Scholar
  16. 16.
    J. D. Bristow, B. E. Van Zee, and M. P. Judkins, Systolic and diastolic abnormalities of the left ventricle in coronary artery disease: studies in patients with little or no enlargement of ventricular volume, Circulation, 42: 219 (1970).CrossRefGoogle Scholar
  17. 17.
    W. H. Gaasch, H. J. Levine, M. A. Quinones, and J. K. Alexander, Left ventricular compliance: mechanisms and clinical implications, Am.J.Cardiol., 38: 645 (1976).CrossRefGoogle Scholar
  18. 18.
    P. E. Pool and E. H. Sonnenblick, The mechanochemistry of cardiac muscles. I. The isometric contraction, J.Gen.Physiol., 50: 951 (1967).CrossRefGoogle Scholar
  19. 19.
    H. Gewirtz, W. Ohley, J. Walsh, D. Shearer, M. Sullivan, and A. S. Most, Ischemia-induced impairment of left ventricular relaxation. Relation to reduced diastolic filling rates of the left ventricle, Am.Heart J., 105: 72 (1983).CrossRefGoogle Scholar
  20. 20.
    J. D. Carrol, O. M. Hess, H. O. Hirzel, and H. P. Krayenbuchil, Exercise-induced ischemia. The influence of altered relaxation on early diastolic pressures, Circulation, 67: 521 (1983).CrossRefGoogle Scholar
  21. 21.
    A. S. Blaustein and W. H. Gaasch, Myocardial relaxation. VI. The effects of left ventricular synchrony and beta adrenergic tone on the load dependency of isovolumic relaxation rate, Am.J.Cardiol., 47: 515 (1981).CrossRefGoogle Scholar
  22. 22.
    H. N. Sabbah and P. D. Stein, Pressure diameter relations during early systole in dogs. Incompatibility with the concept of passive left ventricular filling, Circ.Res., 45: 357 (1981).CrossRefGoogle Scholar
  23. 23.
    J. K. Tyberg, W. J. Keon, E. H. Sonnenblick, and C. W. Urschel, Mechanics of ventricular diastole, Cardiovasc.Res., 4: 423 (1970).CrossRefGoogle Scholar
  24. 24.
    R. O. Bonow, S. L. Bacharach, M. V. Green, K. M. Kent, D. R. Rosing, C. C. Lipson, M. B. Leon, and S. E. Epstein, Impaired left ventricular diastolic fillings in patients with coronary artery disease. Assessment with radionuclide angiography, Circulation, 64: 315 (1981).CrossRefGoogle Scholar
  25. 25.
    L. A. Reduto, W. J. Wichermeyer, J. B. Young, L. A. Del Ventura, J. W. Reid, D. H. Glaeser, M. A. Quinones, and R. R. Miller, Left ventricular diastolic performance at rest and during exercise in patients with coronary artery disease, Circulation, 63: 1228 (1981).CrossRefGoogle Scholar
  26. 26.
    G. B. Mancini, R. A. Slutsky, S. L. Norris, V. Bhargava, W. L. Ashburn, and C. B. Higgins, Radionuclide analysis of peak filling rate, filling fraction, and time to peak filling rate, Am.J.Cardiol., 51: 43 (1983).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • P. Assennato
    • 1
  • B. Candela
    • 1
  • E. Hoffmann
    • 1
  • G. Indovina
    • 1
  • L. Messina
    • 1
  • A. Raineri
    • 1
  1. 1.Cattedra di Fisiopatologia CardiovasolareUniversità di PalermoPoliclinico, PalermoItaly

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