Invasive Assessment of Left Ventricular Function in Ischemic Heart Disease

  • A. Chiddo
  • A. Gaglione
  • D. Quagliara
  • P. Rizzon
Part of the Ettore Majorana International Science Series book series (volume 21)


Left ventricular function considerably affects prognosis and choice of treatment in patients with coronary artery disease (CAD). Nevertheless, a correct assessment of left ventricular (LV) performance, irrespective of the influence of pre- and after-load, is a hard and still unresolved problem, although solving it has been the aim of a number of clinical and experimental studies.


Wall Stress Coronary Artery Disease Patient Left Ventricular Pressure Coronary Artery Disease Group Left Ventricular Relaxation 


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  1. 1.
    K. Sagawa, H. Suga, A. Shoukas, and K. Bakalar, End-systolic Pressure-volume ratio: A new index of ventricular contractility, Am.J.Cardiol., 40: 748 (1977).CrossRefGoogle Scholar
  2. 2.
    K. Sagawa, The end-systolic pressure-volume relation of the ventricle: Definition, modifications and clinical use, Circulation, 63, No. 6: 1223 (1981).CrossRefGoogle Scholar
  3. 3.
    H. Suga and K. Sagawa, Instantaneous pressure-volume relationships and their ratio in the excised, supported canine ventricle, Circulation Res., 35: 117 (1974).CrossRefGoogle Scholar
  4. 4.
    A. Battler, R. Slutsky, J. Karliner, V. Froelicher, W. Ashburn, and J. Ross, Left ventricular ejection fraction and first third ejection fraction early after acute myocardial infarction: Value for predicting mortality and morbidity, Am.J. Cardiol., 45: 197 (1980).CrossRefGoogle Scholar
  5. 5.
    A. Cribier, J. Berland, F. Prigent, and B. Letac, Etude angiographique de la fraction d’éjection par tiers de systole chez le coronarien, Arch.Mal.Coeur., 6: 641–652 (1982).Google Scholar
  6. 6.
    J. G. Dumesnil and R. M. Shoucri, Effect of the geometry of the left ventricle on the calculation of ejection fraction, Circulation, 65, No. 1, 91 (1982).CrossRefGoogle Scholar
  7. 7.
    L. Johnson, K. Ellis, D. Schmidt, and P. J. Cannon, Volume ejected in early systole: A sensitive index of left ventricular performance in coronary artery disease, Circulation, 52: 378 (1975).CrossRefGoogle Scholar
  8. 8.
    R. Slutsky, D. Gordon, J. Karliner, A. Battler, S. Walaski, J. Vaba, M. Pfisterer, K. Peterson, and W. Ashburn, Assessment of early ventricular systole by first pass radionuclide angiography: Useful method for detection of left ventricular dysfunction at rest in patients with coronary artery disease, Am.J.Cardiol., 44: 459 (1979).CrossRefGoogle Scholar
  9. 9.
    R. Slutsky, J. S. Karliner, A. Battler, K. Peterson, and J. Ross, Comparison of early systolic and holosystolic ejection phase indexes by contract ventriculography in patients with coronary artery disease, Circulation, 61, No. 6: 1083 (1980).CrossRefGoogle Scholar
  10. 10.
    J. L. Weiss, J. W. Frederiksen, and M. L. Weisfeldt, Hemodynamic determinants of the time-course of fall in canine left ventricular pressure, J.Clin.Invest., 58: 751–760 (1976).CrossRefGoogle Scholar
  11. 11.
    W. Maughan, K. Sunagawa, and M. L. Weisfeldt, Time constant of relaxation: Influence of peripheral resistance, capacitance and characteristic impedance, Circulation Abstr., 66,Suppl.II (1982).Google Scholar
  12. 12.
    U. Sigwart, M. Grbic, A. Essinger, A. Fischer, D. Morin, and H. Sadeghi, Myocardial function in man during acute coronary ballon occlusion, Circulation Abstr., 66, Suppl.II (1982).Google Scholar
  13. 13.
    I. Mirsky, P. F. Cohn, J. A. Levine, R. Gorlin, M. V. Herman, T. H. Kreulen, and E. H. Sonnenblick, Assessment of left ventricular stiffness in primary myocardial disease and coronary artery disease, Circulation, 50: 128 (1974).CrossRefGoogle Scholar
  14. 14.
    F. Cucchini, G. Baldi, A. L. Barilli, M. DiDonato, and O. Visiolí, Tardokinesis in coronary artery disease: Evidence with instantaneous analysis of left ventricular ejection, Eur.J.Cardiol., 12: 153–166 (1980).Google Scholar
  15. 15.
    D. L. Brutseart, P. R. Housmans, and M. A. Goethals, Dual control of relaxation: Its role in ventricular function in the mammalian heart, Circulation Res., 47, 5: 637 (1980).Google Scholar
  16. 16.
    J. D. Carrol, O. M. Hess, R. Widmer, H. O. Hirzel, and H. P. Krayenbuehl, The nature of inotropic stimulation and diastolic mechanics in man, Circulation, Abstr. 66, Suppl.II (1982).Google Scholar
  17. 17.
    M. M. Conhenye, N. M. DeClerck, M. A. Goethals, and D. L. Brutseart, Relaxation properties of Mammalian atrial muscle, Circulation Res., 48, 3: 352 (1980).Google Scholar
  18. 18.
    M. Hori, M. Inone, M. Fukunami, Y. Ishida, S. Nakajima, M. Kitakaze, A. Kitabatake, and H. Abe, Influence of ejection timing on left ventricular relaxation in isolated canine heart, Circulation Abstr., 66:Suppl. I I (1982).Google Scholar
  19. 19.
    B. S. Lewis and M. S. Gotsman, Current concepts of left ventricular relaxation and compliance, Am.Heart J., 99, 1: 101 (1980).Google Scholar
  20. 20.
    J. D. Carrol, O. M. Hess, H. O. Hirzel, and H. P. Krayenbuehl, Exercise-induced ischemia: The influence of altered relaxation on early diastolic pressure, Circulation, 67,3, 521 (1983).Google Scholar
  21. 21.
    H. Pouleur, M. Rousseau, W. Wijns, P. Mengeot, J. M. Detry, and L. Brasseur, Changes in left ventricular relaxation pattern during atrial pacing in ischemic heart disease, Circulation Abstr., 66:Suppl. I I (1982).Google Scholar
  22. 22.
    J. Tyberg, J. S. Forrester, and W. W. Parmley, Altered segmental function and compliance in acute myocardial ischemia, Eur.J. Cardiol., 1 /3: 307–317 (1974).Google Scholar
  23. 23.
    S. A. Glantz and W. W. Parmley, Factors which affect the diastolic pressure-volume curve, Circulation Res., 42, 2: 171 (1978).Google Scholar
  24. 24.
    A. Blaustein, J. D. Carrol, O. H. L. Bing, and W. H. Gaasch, Preload does not alter myocardial relaxation rate: Studies in the intact heart and isolated muscle, Circulation, Abstr. 66, Suppl.II (1982).Google Scholar
  25. 25.
    A. P. Flessas and T. J. Ryan, Left ventricular diastolic capacity in Man, Circulation, 65, 6: 1197 (1982).Google Scholar
  26. 26.
    H. N. Sabbah and P. D. Stein, Incompatibility with the concept of passive left ventricular filling, Circulation Res., 48, 3: 357 (1981).Google Scholar
  27. 27.
    C. F. Sanford, M. L. Smucker, and K. Lipscomb, Dissociation of impaired left ventricular relaxation and diastolic filling during angina pectoris, Circulation Abstr., 66, Suppl.II (1982).Google Scholar
  28. 28.
    D. S. Thompson, C. B. Waldron, S. M. Juul, N. Nagui, R. H. Swanton, D. J. Coltart, B. S. Jenkins, and M. M. Webb-Peploe, Analysis of left ventricular pressure during isovolumic relaxation in coronary artery disease, Circulation, 65, 4: 690 (1982).Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • A. Chiddo
    • 1
  • A. Gaglione
    • 1
  • D. Quagliara
    • 1
  • P. Rizzon
    • 1
  1. 1.Division of CardiologyUniversity of BariBariItaly

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