Evaluation of Left Ventricular Function in Mitral Regurgitation

  • K. L. Peterson
Part of the Ettore Majorana International Science Series book series (volume 21)


An understanding of the mechanics of left ventricular function in mitral regurgitation necessitates consideration of an acute, as opposed to a chronic, onset of the volume overload. In fact, it is now recognized from both human and experimental animal observations that acute and chronic regurgitation produce congestive heart failure by significantly different pathogenetic mechanisms, Table 1.


Left Atrium Left Ventricular Function Mitral Regurgitation Myocardial Contractility Volume Overload 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    W. C. Roberts, E. Braunwald, and A. G. Morrow, Acute severe mitral regurgitation secondary to ruptured chordae tendineae, Circulation, 33: 58 (1966).CrossRefGoogle Scholar
  2. 2.
    S. Sasayama, M. Takahashi, G. Osakada, K. Hirose, H. Hamashima, E. Nishimura, and C. Kawai, Dynamic geometry of the left atrium and left ventricle in acute mitral regurgitation, Circulation, 60: 177 (1979).CrossRefGoogle Scholar
  3. 3.
    E. H. Sonnenblick, J. Ross Jr., J. W. Covell, H. M. Spotnitz, and D. Spiro, Ultrastructure of the heart in systole and diastole, Circ.Res., 21: 423 (1967).CrossRefGoogle Scholar
  4. 4.
    C. Yoran, J. W. Covell, and J. Ross Jr., Structural basis for the ascending limb of left ventricular function, Circ.Res., 32: 297 (1973).CrossRefGoogle Scholar
  5. 5.
    M. Turina, W. D. Bussman, and H. P. Krayenbuehl, Contractility of hypertrophied canine heart in chronic volume overload, Cardiovasc.Res., 3: 486 (1969).CrossRefGoogle Scholar
  6. 6.
    G. Cooper, F. Puga, K. J. Zujko, C. E. Harrison, and H. N. Coleman, Normal myocardial function and energetics in volume-overload hypertrophy in the cat, Circ.Res., 32: 140 (1973).CrossRefGoogle Scholar
  7. 7.
    J. Ross Jr., and W. H. McCullagh, The nature of enhanced performance of the dilated left ventricle during chronic volume overload, Circ.Res., 30: 549 (1972).CrossRefGoogle Scholar
  8. 8.
    H. Suga, K. Sagawa, and A. A. Shoukas, Load independence of the instantaneous pressure-volume ratio of the canine left ventricle and effects of epinephrine and heart rate on the ratio, Circ.Res., 32: 314 (1973).CrossRefGoogle Scholar
  9. 9.
    K. Sagawa, The end-systolic pressure-volume relation of the ventricle: definition, modifications and clinical use, Circulation, 63: 1223 (1981).CrossRefGoogle Scholar
  10. 10.
    E. Braunwald and W. C. Awe, The syndrome of severe mitral regurgitation with normal left atrial pressure, Circulation, 27: 29 (1963).CrossRefGoogle Scholar
  11. 11.
    W. Grossman, D. Jones, P. McLaurin, Wall stress and patterns of hypertrophy in the human left ventricle, J.Clin.Invest., 56: 56 (1975).CrossRefGoogle Scholar
  12. 12.
    G. Schuler, K. L. Peterson, A. Johnson, G. Francis, G. Dennish, J. Utley, P. 0. Daily, W. Ashburn, and J. Ross Jr., Temporal response of left ventricular performance to mitral valve surgery, Circulation, 59: 1218 (1979).CrossRefGoogle Scholar
  13. 13.
    M. R. Ziles, W. H. Gaasch, J. D. Carroll, and H. J. Levine, Chronic mitral regurgitation: predictive value of preoperative echocardiographic indexes of left ventricular function and wall stress, J.Amer.Coll.Cardiol., 3: 235 (1984).CrossRefGoogle Scholar
  14. 14.
    B. A. Carabello, S. P. Nolan, and B. M. Lockhart, Assessment of preoperative left ventricular function in patients with mitral regurgitation: value of the end-systolic wall stressend-systolic volume ratio, Circulation, 64: 1212 (1981).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • K. L. Peterson
    • 1
  1. 1.University of CaliforniaSan DiegoUSA

Personalised recommendations