Effects of Adrenergic Stimulation on Systolic Time Intervals in Patients with Artificial Pacemaker

  • P. P. Campa
Part of the Ettore Majorana International Science Series book series (volume 21)


The aim of this research was to contribute for a better knowledge of the physiological determinants of the temporal dynamics of the left ventricular chamber contraction. We have studied the effects of adrenergic stimulation on systolic time intervals in patients with artificial pacemaker (PM). These subjects are of considerable pathophysiological interest representing an useful experimental model; compared with subjects with spontaneous electrical activity, patients with PM present: l) a fixed heart rate or only slightly modified heart rate; 2) frequent occurrence, within short time intervals, of systoles with different electrogenesis; 3) abnormal intraventricular conduction. In previous papers[1–5] we have employed the study of systolic time intervals in the pathophysiological investigation of patients with PM; the present report deals with results of a study on the effect of microdoses of epinephrine on systolic time intervals in patients with demand pacemaker presenting, at the time of the study, systoles of different electrogenesis. The microdoses of epinephrine employed may be considered “metabolic”, not unlike the amounts secreted in physiological conditions and without hypertensive effect upon the systemic circulation[6–10].


Saline Infusion Adrenergic Stimulation Rapid Return Sick Sinus Syndrome Systolic Time Interval 
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  1. 1.
    P. P. Campa, P. Tomassíni, G. Speca, P. Di Sabatino, and G. De Curtis, Indagini policardiografiche in portatori di segnapassi artificiale: Effetto dell’attività atriale sulla contrazione ventricolare, Boll.Soc.It.Cardiol., 22: 1632 (1977).Google Scholar
  2. 2.
    P. P. Campa, G. De Curtis, G. Speca, G. Marcellini, and P. Tomassini, Effetto della -metildigossina su alcuni indici policardiografici in portatori di segnapassí artificiale, Boll.Soc.It.Cardiol., 22: 1646 (1977).Google Scholar
  3. 3.
    P. P. Campa, G. Speca, G. De Curtis, and P. Cingoli, Indagini sul controllo neuroumorale dell’attività ventricolare da pacemaker, Giorn.It.Cardiol., 8 (Supp1.3): 156 (1978).Google Scholar
  4. 4.
    P. P. Campa, Adrenergic regulation of ventricular myocardial activity in patients with artificial pacemaker, Bol.Soc. Portuguesa Cardiol., 17 (Suppl.1): 35 (1979).Google Scholar
  5. 5.
    G. Speca, G. Marcellini, P. Pecce, F. Prosperi, C. Napolítano, G. De Curtis, and P. P. Campa, Riflessi atriali e retroconduzione ventricolo-atriale nella malattia del nodo del seno durante elettrostimolazione, Clin.Ter.Cardiovasc., 3: 211 (1982).Google Scholar
  6. 6.
    L. Lundholm, The mechanism of the vasodilatator effect of adrenaline. I. Effect on skeletal muscle vessel, Acta Physiol.Scand., 39: 133 (1956).Google Scholar
  7. 7.
    P. P. Campa, G. Bellisario, F. Pugliese, A. Santucci, and G. Filocamo Jr., Ricerche sull’ effetto dell’infusione di adrenalina sull’attività fosforilasica delle emazie e sulla lattacidemia nelle pecore, Boll.Soc.It.Biol.Sper., 42: 437 (1966).Google Scholar
  8. 8.
    P. P. Campa, A. Santucci, G. Bellisario, S. Rizzo, and G. Calcagnini, Sugli effetti vascolari e metabolici dell’infusione di microdosi di adrenelína in soggetti normali, Progr.Med., 22: 351 (1966).Google Scholar
  9. 9.
    P. P. Campa, A. Santucci, G. Bellisario, S. Rizzo, and A. Parrinello, Ricerche sui rapporti tra attività metabolica ed effetto vasoattivo di infusioni di microdosi di adrenalina in soggetti con splenomegalia congestizía, Progr.Med., 22: 396 (1966).Google Scholar
  10. 10.
    L. Ceremuzynski, K. Herbaczynska-Cedro, B. Broniszewska Ardelt, J. Nauman, A. Nauman, B. Wozniewikz, and J. Laweckí, Evidence for the detrimental effect of adrenaline infused to healthy dogs in doses imitating spontaneous secretion after coronary occlusion, Cardiovasc.Res., 12: 179 (1978).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • P. P. Campa
    • 1
  1. 1.Cattedra di CardiologiaUniversity, L’AquilaItaly

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