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Antigen Mimicry by Anti-Idiotype Antibodies That Recognize a Common Anti-Hepatitis B Surface Antigen Idiotype

  • Ronald C. Kennedy
  • Gordon R. Dreesman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 185)

Abstract

Anti-idiotype antibodies that recognize a common human idiotype present on antibodies to hepatitis B surface antigen (anti-HBs) from individuals naturally infected by hepatitis B virus (HBV) and an interspecies idiotype on anti-HBs produced by active immunization with hepatitis B surface antigen (HBsAg) were used in vivo to modulate idiotype networks in mice. Injection of anti-idiotype antibodies without subsequent HBsAg stimulation induced an anti-HBs response. The anti-idiotype-induced anti-HBs recognized the group-specific a determinant(s) of HBsAg, which has been shown to be responsible for induction of protective immunity to HBV in both chimpanzees and humans. In addition, the anti-HBs expressed an interspecies idiotype which is shared by humans naturally infected with HBV. Prior inoculation of mice with alum-adsorbed anti-idiotype potentiated the immune response to a subsequent inoculation with either native HBsAg particles or with a synthetic HBsAg peptide. These data suggest the potential use of anti-idiotype antibodies as a vaccine or vaccine potentiator for HBV.

Keywords

Cyclic Peptide Idiotype Network Solid Phase Radioimmunoassay Antigen Mimicry HBsAg Subtype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

Anti-HBs

antibodies to hepatitis B surface antigen

Anti-Id

anti-idiotype antibodies

HBsAg

hepatitis B surface antigen

HBV

hepatitis B virus

PFC

plaque forming cells

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Ronald C. Kennedy
    • 1
  • Gordon R. Dreesman
    • 1
  1. 1.Virology and Immunology DepartmentSouthwest Foundation for Biomedical ResearchSan AntonioUSA

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