Antigen Mimicry by Anti-Idiotype Antibodies That Recognize a Common Anti-Hepatitis B Surface Antigen Idiotype

  • Ronald C. Kennedy
  • Gordon R. Dreesman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 185)


Anti-idiotype antibodies that recognize a common human idiotype present on antibodies to hepatitis B surface antigen (anti-HBs) from individuals naturally infected by hepatitis B virus (HBV) and an interspecies idiotype on anti-HBs produced by active immunization with hepatitis B surface antigen (HBsAg) were used in vivo to modulate idiotype networks in mice. Injection of anti-idiotype antibodies without subsequent HBsAg stimulation induced an anti-HBs response. The anti-idiotype-induced anti-HBs recognized the group-specific a determinant(s) of HBsAg, which has been shown to be responsible for induction of protective immunity to HBV in both chimpanzees and humans. In addition, the anti-HBs expressed an interspecies idiotype which is shared by humans naturally infected with HBV. Prior inoculation of mice with alum-adsorbed anti-idiotype potentiated the immune response to a subsequent inoculation with either native HBsAg particles or with a synthetic HBsAg peptide. These data suggest the potential use of anti-idiotype antibodies as a vaccine or vaccine potentiator for HBV.


Cyclic Peptide Idiotype Network Solid Phase Radioimmunoassay Antigen Mimicry HBsAg Subtype 



antibodies to hepatitis B surface antigen


anti-idiotype antibodies


hepatitis B surface antigen


hepatitis B virus


plaque forming cells


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Ronald C. Kennedy
    • 1
  • Gordon R. Dreesman
    • 1
  1. 1.Virology and Immunology DepartmentSouthwest Foundation for Biomedical ResearchSan AntonioUSA

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