Surface Antigens of Bordetella Pertussis
Bordetella pertussis and other Bordetella species cause respiratory infections in humans and in a variety of animals. Clinical isolates of B. pertussis have multiple virulence factors, several of which have been reported to induce protective immunity. Using cell surface iodination techniques and monoclonal antibody immunoblots we have identified several proteins which are exposed on the surface of B. pertussis cells, including the filamentous hemagglutinin and outer membrane proteins 91, 18, and 15. Protein 91 is unique to virulent B. pertussis strains. Antibodies to protein 18 are found in convalescent serum of both humans and mice recovering from infection with B. pertussis.
KeywordsMagnesium Albumin Urea Iodine Pyridine
Unable to display preview. Download preview PDF.
- Ashworth, L., Irons, L., and Dowsett, A., 1982, Antigenic relationship between serotype-specific agglutinogen and fimbriae of Bordetella pertussis, Infect. Immun., 37: 1278–1281.Google Scholar
- Field, L., and Parker, C., 1979, Differences observed between fresh isolates of Bordetella pertussis and their laboratory passaged derivatives, in: “International Symposium on Pertussis,” C. Manclark, and J. Hill, eds., pp. 124–132, DHEW Publication No. (NIH) 79–1830, Washington, D.C.Google Scholar
- Frank, D., and Parker, C., 1984a, Isolation and characterization of monoclonal antibodies to Bordetella pertussis, J. Biologic. Standard., 12: (in press).Google Scholar
- Frank, D., and Parker, C., 1984b, Interaction of monoclonal antibodies with pertussis toxin and its subunits, Infect. Immun., 46: (in press).Google Scholar
- Pittman, M., 1970, Bordetella pertussis: bacterial and host factors in the pathogenesis and prevention of whooping cough, in: “Infectious Agents and Host Reactions,” S. Mudd, ed., pp. 239–270, W. B. Saunders Company, Philadelphia.Google Scholar
- Pusztai, S., and Joo, I., 1967, Influence of nicotinic acid on the antigenic structure of Bordetella pertussis, Ann. Immunol. Hung., 10: 63–67.Google Scholar