Surface Antigens of Bordetella Pertussis

  • Charlotte D. Parker
  • Sandra K. Armstrong
  • Dara W. Frank
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 185)


Bordetella pertussis and other Bordetella species cause respiratory infections in humans and in a variety of animals. Clinical isolates of B. pertussis have multiple virulence factors, several of which have been reported to induce protective immunity. Using cell surface iodination techniques and monoclonal antibody immunoblots we have identified several proteins which are exposed on the surface of B. pertussis cells, including the filamentous hemagglutinin and outer membrane proteins 91, 18, and 15. Protein 91 is unique to virulent B. pertussis strains. Antibodies to protein 18 are found in convalescent serum of both humans and mice recovering from infection with B. pertussis.


Pertussis Toxin Apparent Molecular Weight Bordetella Pertussis Whooping Cough High Molecular Weight Component 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Arai, H., and Sato. Y., 1976, Separation and characterization of two distinct hemagglutinins contained in the purified leukocytosispromoting factor from Bordetella pertussis, Biochem. Biophys. Acta, 444: 765–782.PubMedCrossRefGoogle Scholar
  2. Ashworth, L., Irons, L., and Dowsett, A., 1982, Antigenic relationship between serotype-specific agglutinogen and fimbriae of Bordetella pertussis, Infect. Immun., 37: 1278–1281.Google Scholar
  3. Field, L., and Parker, C., 1979, Differences observed between fresh isolates of Bordetella pertussis and their laboratory passaged derivatives, in: “International Symposium on Pertussis,” C. Manclark, and J. Hill, eds., pp. 124–132, DHEW Publication No. (NIH) 79–1830, Washington, D.C.Google Scholar
  4. Frank, D., and Parker, C., 1984a, Isolation and characterization of monoclonal antibodies to Bordetella pertussis, J. Biologic. Standard., 12: (in press).Google Scholar
  5. Frank, D., and Parker, C., 1984b, Interaction of monoclonal antibodies with pertussis toxin and its subunits, Infect. Immun., 46: (in press).Google Scholar
  6. Goodnow, R., 1980, Biology of Bordetella bronchiseptica, Microbiol. Rev., 44: 722–738.PubMedGoogle Scholar
  7. Hewlett, E., and Wolff, J., 1976, Soluble adenylate cyclase from the culture medium of Bordetella pertussis, J. Bacteriol., 127: 890–898.PubMedGoogle Scholar
  8. Lacey, B. W., 1960, Antigenic modulation of Bordetella pertussis, J. Hyg., 58: 57–93.CrossRefGoogle Scholar
  9. Markwell, M., and Fox, C., 1978, Surface-specific iodination of membranes of viruses and eucaryotic cells using 1,3,4,6tetrachloro-3,6-diphenylglycouril, Biochem., 17: 4807–4817.CrossRefGoogle Scholar
  10. Parton, R., and Wardlow, A. C., 1975, Cell-envelope proteins of Bordetella pertussis, J. Med. Microbiol., 8: 47–57.PubMedCrossRefGoogle Scholar
  11. Pittman, M., 1970, Bordetella pertussis: bacterial and host factors in the pathogenesis and prevention of whooping cough, in: “Infectious Agents and Host Reactions,” S. Mudd, ed., pp. 239–270, W. B. Saunders Company, Philadelphia.Google Scholar
  12. Pusztai, S., and Joo, I., 1967, Influence of nicotinic acid on the antigenic structure of Bordetella pertussis, Ann. Immunol. Hung., 10: 63–67.Google Scholar
  13. Sato, Y., Izumiya, K., Sato, H., Cowell, J., and Manclark, C., 1981, Role of antibody to leukocytosis-promoting factor hemagglutinin and to filamentous hemagglutinin in immunity to pertussis, Infect. Immun., 31: 1223–1231.PubMedGoogle Scholar
  14. Schneider, D., and Parker, C., 1982, Effect of pyridines on phenotypic properties of Bordetella pertussis, Infect. Immun., 38: 548–553.PubMedGoogle Scholar
  15. Standfast, A., 1951, The phase I of Haemophilus pertussis, J. Gen. Microbiol., 5: 531–545.PubMedGoogle Scholar
  16. Wardlow, A. C., and Parton, R., 1983, Bordetella pertussis toxins, Pharmac. Ther., 19: 1–53.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Charlotte D. Parker
    • 1
  • Sandra K. Armstrong
    • 1
  • Dara W. Frank
    • 1
  1. 1.Department of Microbiology; School of MedicineUniversity of MissouriColumbiaUSA

Personalised recommendations