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Pili of Enterotoxigenic Escherichia Coli from Pigs and Calves

  • Richard E. Isaacson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 185)

Abstract

The ability to colonize mucosal surfaces is an important attribute that is required for the virulence of most bacterial pathogens Both invasive and noninvasive bacteria must proliferate and ultimately achieve sufficient populations on mucosal surfaces to cause disease. Various physiologic functions of mammals tend to reduce the size of bacterial populations in vivo. When bacteria are potentially pathogenic, these functions provide a defensive mechanism against disease. The flow of fluids and particulate matter in small intestines due to peristalsis and villus pumping helps to keep bacterial populations low. In the small intestines of man where bacterial populations are normally small, any overgrowth that results from a cesation of flow has the potential to be coupled to a disease process. In the large intestine, where the rate of flow becomes quite slow, bacterial populations are naturally higher and ecologically complex.

Keywords

Porcine Small Intestine ETEC Strain Neonatal Diarrhea Receptor Recognition Site ETEC Challenge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Richard E. Isaacson
    • 1
  1. 1.Pfizer Central ResarchGrotonUSA

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