Rotavirus Antigens

  • Mary K. Estes
  • David Y. Graham
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 185)


The rotaviruses are important medical and veterinary pathogens that cause acute diarrheal disease in children and in the young of most mammalian and avian species. The successful development of a rotavirus vaccine should significantly reduce worldwide infant morbidity and mortality and economic losses and increase food-production. Recent successes in the cultivation and characterization of rotavirus strains from humans and animals have led to a better understanding of the major antigens of these viruses and the genes encoding these antigens. The products of three independent genes (1) the neutralization antigen (the outer capsid glycoprotein); (2) the subgroup antigen (the major inner capsid protein); and (3) the hemagglutinin (the outer capsid protease-sensitive protein) are the major viral antigens. The properties and structure of these antigens are discussed. Further knowledge should facilitate the synthesis and development of novel antigen or subunit vaccines.


Immune Electron Microscopy Monospecific Antiserum Acute Diarrheal Disease Neutralization Antigen Immune Electron Microscopy Study 


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Mary K. Estes
    • 1
  • David Y. Graham
    • 1
  1. 1.Departments of Virology and Epidemiology and of MedicineBaylor College of MedicineHoustonUSA

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