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Neuronal and Glial Pathologies: Morphology and Physiology of Human and Monkey Epileptic Foci

  • A. A. WardJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 203)

Abstract

Focal epilepsy in the human is characterized by the occurrence of chronic, spontaneous seizures. The animal model that best approximates the histological characteristics, natural history and electrophysiological properties of the human condition is the chronic monkey model in which the cortical focus is induced by the subpial injection of alumina gel (Lockard and Ward, 1980). The seizures become clinically apparent many weeks after the cortical scarring has stabilized. They are of focal onset, occur spontaneously at random intervals and, once their pattern is established, their frequency is relatively constant and the epilepsy appears to persist indefinitely.

Keywords

Seizure Frequency Excitatory Amino Acid Interspike Interval Focal Epilepsy Epileptic Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • A. A. WardJr.
    • 1
  1. 1.Department of Neurological SurgeryUniversity of Washington School of MedicineSeattleUSA

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