Cytochemical Architecture of the Entorhinal Area

  • Ch. Köhler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 203)


The hippocampal region1) consists of serially arranged cortical fields which become increasingly simplified in their basic laminar structure as one proceeds from the entorhinal area (EA) to the area dentata (Swanson, 1982b; Fig. 1). The EA is the largest retrohippocampal subfield and it gives rise to one of the most prominent association pathways within the entire hippocampal region. This pathway, the perforant path, originates primarily from stellate and pyramidal cells in layers II and III of the medial and the lateral EA, and terminates in the dentate gyrus where it synapses onto the granular cell dendrites in the outer two-thirds of the molecular layer (Blackstad, 1958; Hjorth-Simonsen, 1971; Steward and Scoville, 1976). The medial EA, in turn, receives a topographically organized input from the subfields of the subicular complex: the deep layers of the EA are innervated by the subiculum proper and the outer three layers by the para- and presubiculum, respectively (Shipley, 1975; Köhler, 1985). It is through these latter projections that thalamic as well as some commissural inputs are relayed to the EA, and the association pathways from the subicular complex to the medial EA represent important routes through which afferents of extra-hippocampal origin may affect neurotransmission along the perforant path.


Vasoactive Intestinal Peptide Vasoactive Intestinal Polypeptide Glutamic Acid Decarboxylase Hippocampal Region Perforant Path 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Ch. Köhler
    • 1
  1. 1.Department of NeuropharmacologyAstra Läkemedel ABSödertäljeSweden

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