Glutamate and Anoxic Neuronal Death in Vitro

  • S. M. Rothman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 203)


Identifying the factors responsible for the exquisite sensitivity of the brain to anoxia and ischemia has been very difficult with currently available preparations. During the past three years, our laboratory has utilized two fairly well characterized in vitro preparations to study the effects of anoxia on central mammalian neurons. The experiments described below, which employed cultures of dissociated hippocampal neurons and slices of rat hippocampus, implicate the synaptic release of glutamate (Glu) in the pathophysiology of anoxic neuronal death.


Excitatory Amino Acid Synaptic Activity Hippocampal Culture Excitatory Amino Acid Receptor Synaptic Release 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • S. M. Rothman
    • 1
  1. 1.Departments of Pediatrics, Anatomy and Neurobiology, and NeurologyWashington University School of MedicineSt. LouisUSA

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