Selective and Non-Selective Seizure Related Brain Damage Produced by Kainic Acid

  • Y. Ben-Ari
  • A. Repressa
  • E. Tremblay
  • L. Nitecka
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 203)

Abstract

Parenteral or intracerebral administration of the potent excitatory amino acid kainic acid (KA) produces a seizure and brain damage syndrome in which limbic structures play a central role. This has been investigated extensively, notably since it constitutes a useful animal model of human temporal lobe epilepsy. In the present report, I shall briefly discuss a number of aspects concerning these actions of KA — in particular the effects produced by parenteral injections of the toxin (e.g., Ben-Ari, 1985 for a recent review).

Keywords

Zinc Permeability Toxicity Saccharose Dioxide 

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Y. Ben-Ari
    • 1
    • 2
  • A. Repressa
    • 1
    • 2
  • E. Tremblay
    • 1
    • 2
  • L. Nitecka
    • 1
    • 2
  1. 1.LPN, CNRSGif-sur-YvetteFrance
  2. 2.Port-Royal Hôpital de Port-RoyalParisFrance

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