Amino Acid Activated Receptor-Channels at Peripheral and Central Synapses

  • S. G. Cull-Candy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 203)


Synaptic channels opened by glutamate and GABA have been examined in locust muscle fibers and cultured cerebellar neurons of the rat. In both systems, the receptors are readily accessible to techniques such as noise analysis (Katz and Miledi, 1972; Anderson and Stevens, 1973) and single channel recording (Neher et al., 1978; Hamill et al., 1981), allowing basic information to be obtained about amino acid activated receptor-channels.


Single Channel Glutamate Concentration Patch Pipette Single Channel Conductance Membrane Patch 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • S. G. Cull-Candy
    • 1
  1. 1.MRC Receptor Mechanisms Research Group Department of PharmacologyUniversity College LondonUK

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