Blockade by D-Aminophosphonovalerate or Mg2+ of Excitatory Amino Acid-Induced Responses on Spinal Motoneurons in Vitro
L-glutamate and its structurally-related analogs are known to evoke strong excitation of vertebrate central neurons (Nistri and Constanti, 1979; Puil, 1981). Pharmacological studies have shown that there are probably distinct receptor populations mediating responses to different excitatory amino acids (Watkins and Evans, 1981; McLennan, 1983): one receptor class is preferentially activated by N-methyl-D-aspartate (NMDA) while a separate receptor type selectively binds quisqualate. While it is not fully clear if kainate operates via a third receptor system, it seems that the endogenously occurring amino acids L-glutamate and L-aspartate have mixed agonist properties being able to bind NMDA as well as quisqualate receptors.
KeywordsExcitatory Amino Acid Spinal Motoneuron Excitatory Amino Acid Receptor EPSP Amplitude Control Ringer
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