Excitatory Amino Acids and Regenerative Activity in Cultured Neurons

  • J. F. MacDonald
  • J. H. Schneiderman
  • Z. Miljkovic
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 203)


Hayashi (1954) originally demonstrated that the application of glutamic acid to the cortical surface of dogs evoked convulsions. Later, excitatory amino acids (EAA), such as L-glutamic and L-aspartic acid, were proposed as possible transmitter candidates suggesting that dysfunction of these transmitters might contribute to convulsions.


Excitatory Amino Acid Voltage Clamp Current Clamp Current Plateau Depolarize Voltage Step 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. F. MacDonald
    • 1
  • J. H. Schneiderman
    • 1
  • Z. Miljkovic
    • 1
  1. 1.Playfair Neuroscience Unit, University of TorontoToronto Western and Wellesley HospitalsTorontoCanada

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