Abstract
In spite of the availability of a relatively large number of antiepileptic drugs, the search for new, effective yet non-toxic antiepileptic drugs still goes on. Today as in the past, the prime strategy in this search remains the screening of potential drugs in two established seizure models, i.e., the maximal electroshock seizure test and the subcutaneous metrazol seizure threshold test. The compounds passing successfully the tests of long term efficacy, toxicity and pharmacokinetics undergo clinical trials and may eventually be recommended as drugs, often in spite of the partial or even lack of knowledge concerning the mechanism of their anticonvulsant action. The relative success of this screening approach can be judged by the fact that only three new antiepileptic drugs (carbamazepine, clonazepam and valproic acid) have been marketed in the last 25 years.
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© 1986 Plenum Press, New York
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Teichberg, V.I. et al. (1986). Na+ Fluxes as a Tool to Identify Anticonvulsant Antagonists of Neuroexcitation. In: Schwarcz, R., Ben-Ari, Y. (eds) Excitatory Amino Acids and Epilepsy. Advances in Experimental Medicine and Biology, vol 203. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7971-3_22
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DOI: https://doi.org/10.1007/978-1-4684-7971-3_22
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