Excitatory Amino Acid Pathways in the Brain

  • O. P. Ottersen
  • J. Storm-Mathisen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 203)


The neurochemical techniques used to obtain the results reviewed here take advantage of the fact that chemical neurotransmission requires 1) the presence of the transmitter in the presynaptic element, 2) a synthesizing apparatus for transmitter replenishment, 3) a mechanism for transmitter release, and 4) a mechanism for terminating transmitter action, involving, in the case of excitatory amino acids (EAA), reuptake in the presynaptic element. These techniques alone do not give definitive proof of the transmitter identity, but positive results with any one of them in a neuronal system suggest that the possibility of EAA neurotransmission should be more closely investigated, including also electrophysiological and pharmacological methods.


Superior Colliculus Excitatory Amino Acid Cochlear Nucleus Perforant Path Olfactory Cortex 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • O. P. Ottersen
    • 1
  • J. Storm-Mathisen
    • 1
  1. 1.Anatomical InstituteUniversity of OsloOslo 1Norway

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