Pathophysiological Aspects of Blood-Brain Barrier Permeability in Epileptic Seizures

  • C. Nitsch
  • G. Goping
  • I. Klatzo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 203)


Blood-brain barrier (BBB) permeability to macromolecules was assessed during seizures induced by pentylenetetrazole, bicuculline, methoxypyridoxine, methionine sulfoximine, and kainic acid. It was observed that each convulsant induced a specific pattern of regional BBB opening, This was, however, only the case when systemic blood pressure (BP) rose with seizure onset. The analysis of regional cerebral blood flow revealed that a high increase in flow in rabbits with BP rise is related to the normal flow at rest in the single brain region, but not to BBB permeability. In rabbits without BP increase, regional flow increase was low but well modulated and is possibly a better indicator for neuronal activity. The ultrastructural analysis showed that macromolecular transport over the cerebrovascular endothelium is by pinocytosis, an neurotransmitter controlled process.It is suggested that seizure-induced regional BBB opening is determined by two factors: release of neurotransmitters due to the process of autoregulation during peripheral pressure increase, and change in local neurotransmitter milieu due to the action of the convulsant and/or the seizure activity.


Inferior Colliculus Evans Blue Kainic Acid Seizure Onset Pinocytotic Vesicle 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • C. Nitsch
    • 1
    • 2
  • G. Goping
    • 1
    • 2
  • I. Klatzo
    • 1
    • 2
  1. 1.Laboratory of Neuropathology and Neuroanatomical SciencesNINCDS, NIHBethesdaUSA
  2. 2.(C.N.) Anatomical InstituteUniversity of MunichMünchen 2Germany

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