Long Term Sequelae of Parenteral Administration of Kainic Acid

  • L. Nitecka
  • E. Tremblay
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 203)


Neuronal loss and the development of gliotic scars in various brain regions, in particular in limbic structures, following administration of kainic acid (KA) has been extensively described in the literature (Olney et al. 1979; Ben-Ari et al., 1980; Nadler et al., 1980; Schwob et al., 1980; Ben-Ari et al., 1981; Lothman and Collins, 1981; French et al., 1982; Nitecka et al., 1984; Ben-Ari, 1985). The pattern of brain damage is reminiscent of that seen in human temporal lobe epileptics (Falconer et al., 1964; Margerison and Corsellis, 1966; Brown, 1973; Scheibel and Scheibel, 1973; Scheibel et al., 1974; Dam, 1980).


Neuronal Loss Temporal Lobe Epilepsy Hippocampal Formation Kainic Acid Cresyl Violet 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • L. Nitecka
    • 1
    • 2
  • E. Tremblay
    • 1
  1. 1.LPN, CNRSGif-sur-YvetteFrance
  2. 2.Department of Anatomy of the Medical Academy of GdanskPoland

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