Genetics of Pattern Formation

  • Peter J. Bryant
  • Jack R. Girton
Part of the Basic Life Sciences book series (BLSC, volume 16)


Over the last few decades, studies of pattern formation in Drosophila imaginal discs have been proceeding along two rather separate lines. One line of research includes the studies initiated by Vogt, Bodenstein and the Hadorn group on the experimental embryology of imaginal discs, where the ability of disc fragments to grow, to regenerate, and to duplicate has been documented (see Bryant, 1978 for review). This has led to a number of theories involving first, gradients of developmental capacity (Bryant, 1971) and second, a polar coordinate system in which any discontinuities are eliminated by intercalation (French, Bryant, and Bryant, 1976).


Pattern Formation Imaginal Disc Wing Disc Imaginal Wing Disc Tarsal Segment 
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  1. Arking, R., 1975, Temperature-sensitive cell-lethal mutants of Drosophila: Isolation and characterization, Genetics, 80: 519.Google Scholar
  2. Bateson, W., 1894, “Materials for the Study of Variation”, MacMillan, London.Google Scholar
  3. Bohn, H., 1965, Analyse der Regenerationsfähigkeit der Insektenextremität durch Amputations-und Transplantationsversuch an Larven der afrikanischen Schabe (Leucophaea maderae Fabr.). II. Achsendetermination, Wilhelm Roux Arch., 156: 449.CrossRefGoogle Scholar
  4. Bohn, H., 1972, The origin of the epidermis in the supernumerary regenerates of triple legs in cockroaches (Blattaria), J. Embryol. Exp. Morph., 28:184.Google Scholar
  5. Bryant, P.J., 1971, Regeneration and duplication following operations in situon the imaginal discs of Drosophila melanogaster, Develop. Biol., 26: 637.Google Scholar
  6. Bryant, P.J., 1975, Pattern formation in the imaginal wing disc of Drosophila melanogaster: Fate map, regeneration and duplication, J. Exp. Zool., 193: 49.PubMedCrossRefGoogle Scholar
  7. Bryant, S.V., 1976, Regenerative failure of double half limbs in Notophthalmus viridescens, Nature, 263: 676.PubMedCrossRefGoogle Scholar
  8. Bryant, S.V., and Baca, B., 1978, Regenerative ability of double half and half upper arms in the newt, Notophthalmus viridescens, J. Exp. Zool., 204: 307.PubMedCrossRefGoogle Scholar
  9. Clark, W.C.,and Russell, M.A., 1977, The correlation of lysosomal activity and adult phenotype in a cell-lethal mutant of Drosophila, Develop. Biol., 57: 160.Google Scholar
  10. Duranceau, C., 1977, Control of growth and pattern formation in the imaginal wing disc of Drosophila melanogaster, Ph.D. Thesis, University of California, Irvine.Google Scholar
  11. French, V., 1978, Intercalary regeneration around the circumference of the cockroach leg, J. Embryol. Exp. Morph., 47: 53.PubMedGoogle Scholar
  12. French, V., Bryant, P.J.,and Bryant, S.V., 1976, Pattern regulation in epimorphic fields, Science, 193: 969.PubMedCrossRefGoogle Scholar
  13. Fristrom, D., 1968, Cellular degeneration in wing development of the mutant vestigialof Drosophila melanogaster, J. Cell Biol., 39: 488PubMedCrossRefGoogle Scholar
  14. Garcia-Bellido, A., 1975, Genetic control of wing disc development in Drosophila, Ciba Found. Symp., 29: 161.PubMedGoogle Scholar
  15. Garcia-Bellido, A., Ripoll, P.,and Morata, G., 1973, Developmental compartmentalization of the wing disc of Drosophila, Nature New Biol., 245: 251.PubMedGoogle Scholar
  16. Girton, J.R.,and Russell, M.A., 1980, A clonal analysis of pattern duplication in a temperature-sensitive cell-lethal mutant of Drosophila melanogaster, Develop. Biol., in apress.Google Scholar
  17. Jurgens, G.,and Gateff, E., 1979, Pattern specification in imaginal disLS Vl D1osupllild melanogasterdevelopmental analysis of a temperature-sensitive mutant producing duplicated legs, Wilhelm Roux Arch., 186: 1.CrossRefGoogle Scholar
  18. Morata, G.,and Lawrence, P.A., 1977, The development of wingless, a homoeotic mutation of Drosophila, Develop. Biol., 56: 227.CrossRefGoogle Scholar
  19. Postlethwait, J.H., 1975, Pattern formation,in the wing and haltere imaginal discs after irradiation of Drosophila melanogasterfirst instar larvae, Wilhelm Roux Arch., 178: 29.CrossRefGoogle Scholar
  20. Postlethwait, J.H., 1978, Development of cuticular patterns in the legs of a cell lethal mutant of Drosophila melanogaster, Wilhelm Roux Arch., 185: 37.CrossRefGoogle Scholar
  21. Rahn, P., 1972, Untersuchungen zur Entwicklung von Ganz-und Teilimplantaten der Flugelimaginalscheibe von Ephestia kuhniella Z, Wilhelm Roux Arch., 170: 48.CrossRefGoogle Scholar
  22. Rose, S.M., 1962, Tissue-arc control of regeneration in the amphibian limb, Symp. Soc. Study Develop. Growth, 20: 153.Google Scholar
  23. Russell, M.A., 1974, Pattern formation in the imaginal discs of a temperature-sensitive cell-lethal mutant of Drosophila melanogaster, Develop. Biol., 40: 24.Google Scholar
  24. Russell, M.A., Girton, J.R.,and Morgan, K., 1977, Pattern formation in a ts-cell-lethal mutant of Drosophila: the range of phenotypes induced by larval heat treatments, Wilhelm Roux Arch., 183: 41.CrossRefGoogle Scholar
  25. Schubiger, G., 1971, Regeneration, duplication and transdetermination in fragments of the leg disc of Drosophila melanogaster, Develop. Biol., 26: 277.PubMedCrossRefGoogle Scholar
  26. Schubiger, G. and Schubiger, M., 1978, Distal transformation in Drosophilaleg imaginal disc fragments, Develop. Biol., 67: 286.PubMedCrossRefGoogle Scholar
  27. Simpson, P.,and Schneiderman, H.A., 1975, Isolation of temperaturesensitive mutations blocking clone development in Drosophila melanogaster, and the effects of a temperature sensitive cell lethal mutation on pattern formation in imaginal discs, Wilhelm Roux Arch., 178: 247.CrossRefGoogle Scholar
  28. Stern, C., 1968, “Genetic Mosaics and Other Assays”, Harvard University Press, Cambridge, Massachusetts.Google Scholar
  29. Strub, S., 1977a, Pattern regulation and transdetermination in Dro- sophilaimaginal leg disc reaggregates, Nature, 269: 688.CrossRefGoogle Scholar
  30. Strub, S., 1977b, Developmental potentials of the cells of the male foreleg disc of Drosophila, Wilhelm Roux Arch., 182: 75.CrossRefGoogle Scholar
  31. Tank, P.W., 1978, The failure of double-half forelimbs to undergo distal transformation following amputation in the axolotl, Ambystoma mexicanum. J. Exp. Zool., 204: 325.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Peter J. Bryant
    • 1
  • Jack R. Girton
    • 1
  1. 1.Developmental Biology CenterUniversity of California, IrvineIrvineUSA

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