Advertisement

Sensory Pathways in Drosophila Central Nervous System

  • Alain Ghysen
  • Renaud Janson
Part of the Basic Life Sciences book series (BLSC, volume 16)

Summary

We have analyzed the central projections of identified sensory neurons in wild type Drosophila and in the homeotic mutant bithorax postbithorax The results indicate that: (i) the choice of a given pathway in the central nervous system of the adult depends on the developmental history of the neuron, namely on the type of sense organ of which it is part, and on the developmental compartment to which it belongs; (ii) the establishment of the projection involves the specific recognition of a preexisting “trail” in the central nervous system. Here we examine and rule out alternative explanations of our results, and conclude that the directed growth of an axon relies at least in part on a physical guidance mechanism to which specificity is conferred by programming the growing axon to recognize the appropriate guide.

We speculate that the guides are preexisting, specifically marked nerve fibers and that the basic pattern of connectivity is largely laid down early during neurogenesis, at a time when a standard set of connections is relatively easy to specify.

Keywords

Sensory Neuron Wing Disc Sensory Pathway Thoracic Ganglion Campaniform Sensilla 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

References

  1. 1.
    S. Benzer, Genetic dissection of behavior, Sci. Amer. 229(6): 24 (1973).Google Scholar
  2. 2.
    Y.N. Jan, L.Y. Jan and M.J. Dennis, Two mutations of synaptic transmission in Drosophila, Proc. R. Soc. Lond. B 198: 87 (1977).CrossRefGoogle Scholar
  3. 3.
    Y.N. Jan and L.Y. Jan, Genetic dissection of short term and long term facilitation at the Drosophila neuromuscular junction, Proc. Natl. Acad. Sci. USA 75: 515 (1978).Google Scholar
  4. 4.
    O. Siddiqi and S. Benzer, Neurophysiological defects in temperature-sensitive paralytic mutants of Drosophila melanogaster, Proc. Natl. Acad. Sci. USA 73: 3253 (1976).CrossRefGoogle Scholar
  5. 5.
    W.G. Quinn’and J.L. Gould, Nerves and genes, Nature 278: 19 (1979).CrossRefGoogle Scholar
  6. 6.
    E.B. Lewis, A gene complex controlling segmentation in Drosophila Nature 276: 565 (1978).CrossRefGoogle Scholar
  7. 7.
    A.Garcia-Bellido, P. Ripoll and G. Morata, Developmental compartmentalization of the wing disc of Drosophila, Nature New Biol., 245: 251 (1973).Google Scholar
  8. 8.
    A. Garcia-Bellido and M.P. Capdevila, Initiation and maintenance of gene activity in a developmental pathway of Drosophila, in: The Clonal Basis of Development“, S. Sobtenly and I.M. Sussex, eds., Academic Press, New York, pp. 3–21 (1979).Google Scholar
  9. 9.
    W.J. Gehring and R. Nöthiger, The imaginal discs of Drosophila, in: “Developmental Systems: Insects”, Vol. 2, S.J. Counce and C.H. Waddington, eds., Academic Press, New York, pp. 211–290, (1973).Google Scholar
  10. 10.
    G. Morata and P.A. Lawrence, Homeotic genes, compartments and cell determination in Drosophila, Nature 265: 211 (1977).PubMedCrossRefGoogle Scholar
  11. 11.
    I.I. Deak, Demonstration of sensory neurons in the ectopic cuticle of spineless-aristapedia, a homoeotic mutant of Drosophila, Nature 260: 252 (1976).PubMedCrossRefGoogle Scholar
  12. 12.
    R.F. Stocker, J.S. Edwards, J. Palka and G. Schubiger, Projections of sensory neurons from a homoeotic mutant appendage, Antennapedia, in Drosophila melanogaster, Develop. Biol. 52:210 (1976).Google Scholar
  13. 13.
    J. Palka, P.A. Lawrence and H.S. Hart, Neural projection patterns from homoeotic tissue of Drosophila studied in bithorax mutants and mosaics, Develop. Biol. 69: 549 (1979).Google Scholar
  14. 14.
    A. Ghysen, Sensory neurons recognize defined pathways in Drosophila central nervous system, Nature 274: 869 (1978).CrossRefGoogle Scholar
  15. 15.
    H. Anderson and J. Bacon, Developmental determination of neuronal projection patterns from wind sensitive hairs in the locus, Schistocerca gregaria, Develop. Biol. 72: 364 (1979).Google Scholar
  16. 16.
    A.Ghysen, The projection of sensory neurons in the central nervous system of Drosophila: Choice of the appropriate pathway, Develop. Biol. (in press) (1980).Google Scholar
  17. 17.
    Reviewed in: C.M. Bate, Development of sensory systems in arthropods, in: “Handbook of Sensory Physiology” Vol. IX, M. Jacobson ed., pp. 1–53 (1978).Google Scholar
  18. 18.
    G. Morata and P.A. Lawrence, Control of compartment development by the engrailed gene of Drosophila’, Nature 255: 614 (1975).PubMedCrossRefGoogle Scholar
  19. 19.
    A. Garcia-Bellido, Pattern reconstruction by dissociated imaginal disc cells of Drosophila melanogaster, Develop. Biol. 14: 278. (1966).Google Scholar
  20. 20.
    V.B. Wigglesworth, The origin of sensory neurons in an insect, Quart. J. Microsc. Sci. 94: 93 (1953).Google Scholar
  21. 21.
    C.M. Bate, Pioneer neurons in an insect embryo, Nature 260: 54 (1976).PubMedCrossRefGoogle Scholar
  22. 22.
    J.R. Sanes and J.G. Hildebrand, Nerves in the antenna of pupal Manduca sexta, Wilhelm Roux Arch. 178: 71 (1975).CrossRefGoogle Scholar
  23. 23.
    A. Ghysen and I.I. Deak, Experimental analysis of sensory nerve pathways in Drosophila, Wilhelm Roux Arch. 184: 273 (1978).CrossRefGoogle Scholar
  24. 24.
    M.J. Katz and R.J. Lasek, Substrate pathways which guide growing axons in Xenopus embryos, J. Comp. Neurol. 183: 817 (1979).Google Scholar
  25. 25.
    R.P. Sharma and V.L. Chopra, Effect of the wingless mutation on wing and haltere development in Drosophila melanogaster, Develop. Biol. 48: 461 (1976).Google Scholar
  26. 26.
    M.E. Power, The thoracico-abdominal nervous system of an adult insect, Drosophila melanogaster, J. Comp. Neurol. 88: 347 (1948).Google Scholar

References for Appendix Only

  1. 1.
    R.P. Sharma, wingless, a new mutant in Drosophila melanogaster, Droso. Inf. Serv. 50: 134 (1973).Google Scholar
  2. 2.
    R.P. Sharma and V.L. Chopra, Effect of wingless mutation on wing and haltere development in Drosophila melanogaster, Develop. Biol. 28: 461.Google Scholar
  3. 3.
    P.J. Bryant, Pattern formation in the imaginal wing disc of Drosophila melanogaster: fate map, regeneration and duplication, J. exp. Zool. 183: 49 (1975).CrossRefGoogle Scholar
  4. 4.
    J.H. Postlethwait, Pattern formation in the wing and haltere imaginal discs after irradiation of Drosophila melanogaster first instar larvae, Wilhelm Roux’ Arch. 178: 29 (1975).Google Scholar
  5. 5.
    P. Babu, Early developmental subdivisions of the wing disc in Drosophila,Molec. Gen. Genet. 151: 289 (1977).Google Scholar
  6. 6.
    G. Morata and P.A. Lawrence, The development of wingless, a homeotic mutation of Drosophila, Develop. Biol. 56: 227 (1977).Google Scholar
  7. 7.
    A. Garcia-Bellido, P. Ripoll and G. Morata, Developmental compartmentalization of the wing disc of Drosophila, Nature New Biol. 245: 251 (1973).PubMedGoogle Scholar
  8. 8.
    A. Garcia-Bellido and P. Santamaria, Developmental analysis of the wing disc in the mutant engrailed of Drosophila melanogaster, Genetics 72: 87 (1972).PubMedGoogle Scholar
  9. 9.
    G. Morata and P.A. Lawrence, Control of compartment development by the engrailed gene of Drosophila, Nature 255: 614 (1975).PubMedCrossRefGoogle Scholar
  10. 10.
    I.I. Deak, Thoracic duplications in the mutant wingless of Drosophila and their effect on muscles and nerves, Develop. Biol. 66: 422 (1978).Google Scholar
  11. 11.
    A. Ghysen and I.I. Deak, Experimental analysis of sensory nerve pathways in Drosophila, Wilhelm Roux Arch. 184: 273 (1978).CrossRefGoogle Scholar
  12. 12.
    C.A. Reinhardt, N.M. Hodgkin and P.J. Bryant, Wound healing in the imaginal discs of Drosophila, I. Scanning electron microscopy of normal and healing wing discs, Develop. Biol. 60: 238 (1977).Google Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Alain Ghysen
    • 1
  • Renaud Janson
    • 1
  1. 1.Laboratoire de GénétiqueUniversité Libre de BruxellesBelgium

Personalised recommendations