What is the Normal Function of Genes which Give Rise to Homeotic Mutations?
A homeotic mutation may be defined as one which causes a transformation of the determined state of some or all of the cells of a particular imaginal disc or disc compartment of the determined state characteristic of some other disc or disc compartment. Mutations such as these have been intriguing geneticists and developmental biologists for more than fifty years because they seem to offer insight into how genes control developmental processes. A fundamental question raised by their very existence concerns the nature of the normal functions of those genes which can give rise to such homeotic mutations.
KeywordsPositional Information Imaginal Disc Larval Period Determined State Wing Structure
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- Garcia-Bellido, A., 1977, Homeotic and atavic mutations in insects, Amer. Zool., 17: 613.Google Scholar
- Hadorn, E., 1978, Imaginal Discs: Transdetermination, in:“The Genetics and Biology of Drosophila, Vol. 2c”, M. Ashburner and T.R.F. Wright, eds., Academic Press, London.Google Scholar
- LeCalvez, J., 1948, In(3R)ssAr: Mutation aristapedia héterozygote dominant, homozygote léthale chez Drosophila melanogaster, Bull. Biol. France Belg., 82: 97.Google Scholar
- Lewis, E.B., 1964, Genetic control and regulation of pathways, in: “The Role of Chromosomes in Development”, M. Locke, ed., Academic Press, New York.Google Scholar
- Shearn, A., 1978, Mutational dissection of imaginal disc development, in: “Genetics and Biology of Drosophila, Vol.2C”, M. Ashburner and T.R.F. Wright,, eds., Academic Press, London.Google Scholar