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An Analysis of the Expressivity of Some Bithorax Transformations

  • Gines Morata
  • Stephen Kerridge
Part of the Basic Life Sciences book series (BLSC, volume 16)

Abstract

Of the homeotic mutants known in Drosophila, those of the bithorax system are by far the best known genetically, thanks to the extensive analyses by E.B. Lewis (1963, 1964, 1967, 1978). The interest of their study lies not only in their effect on the development of certain segments (see Morata and Lawrence, 1977) but also in the genetic structure of the system; it has been shown that the bithorax genes are organized in a gene complex which includes several adjacent loci: bithorax (bx), Contrabithorax (Cbx), Ultrabi-thorax (Ubx), bithoraxoid (bxd), postbithorax (pbx), Hyperabdominal (Hab), Ultraabdominal (Uab), and probably others. These genes seem to be under the same control elements. (See Lewis, 1978 for a recent review.) This gene complex is one of the few examples studied and characterized in eukaryotes. In general (but not always) each of these loci is associated with one particular type of homeotic transformation; a specific segment or half-segment is transformed into another.

Keywords

Notum Structure Homeotic Transformation Hypomorphic Mutant Compartment Boundary Homeotic Mutant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Garcia-Bellido, A., Ripoll, P., and Morata, G., 1973, Developmental compartmentalization of the wing disc of Drosophila, Nature New Biol., 245: 251.PubMedGoogle Scholar
  2. Garcia-Bellido, A., Ripoll, P., and Morata, G., 1976, Developmental compartmentalization in the dorsal mesothoracic disc of Drosophila, Devel. Biol., 48: 132.Google Scholar
  3. Garcia-Bellido, A., and Lewis, E.B., 1976, Autonomous cellular differentiation of homoeotic bithorax mutants of Drosophila melano-gaster, Devel. Biol., 48: 400.CrossRefGoogle Scholar
  4. Lawrence, P.A., Struhl, G., and Morata, G., 1979, Bristle patterns and compartment boundaries in the tarsi of Drosophila, J. Embryol. Exp. Morph., 51: 195.PubMedGoogle Scholar
  5. Lewis, E.B., 1963, Genes and developmental pathways, Amer. Zool., 3: 33Google Scholar
  6. Lewis, E.B., 1964, Genetic control and regulation of developmental pathways, in: “The Role of Chromosomes in Development”, M. Locke, ed., Academic Press, New York, pp. 232–251.Google Scholar
  7. Lewis, E.B., 1967, Genes and gene complexes, in: “Heritage from Mendel”, A. Brink, ed., University of Wisconsin Press, Madison, pp. 17–41.Google Scholar
  8. Lewis, E.B., 1978, A gene complex controlling segmentation in Drosophila, Nature, 276: 565.PubMedCrossRefGoogle Scholar
  9. Lindsley, D.L. and Grell, E.H., 1968, Genetic variations of Drosophila melanogaster, Carnegie Inst. Washington, Publ. No. 627.Google Scholar
  10. Morata, G., 1975, Analysis of gene expression during the development in the homoeotic mutant Contrabithoraxof Drosophila, J. Embryol. Exp. Morph., 34: 19.PubMedGoogle Scholar
  11. Morata, G., and Garcia-Bellido, A., 1976, Developmental analysis of some mutants of the bithoraxsystem of Drosophila, Wilhelm Roux Arch., 179: 125.CrossRefGoogle Scholar
  12. Morata, G., and Lawrence, P.A., 1977, Homoeotic genes, compartments and cell determination in Drosophila, Nature, 265: 211PubMedCrossRefGoogle Scholar
  13. Tokunaga, C., 1961, The differentiation of a secondary sex comb under the influence of the gene engrailed in Drosophila melanogaster, Genetics, 46: 157.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Gines Morata
    • 1
  • Stephen Kerridge
    • 1
  1. 1.Centro de Biologia MolecularUniversidad Autónoma de MadridMadrid-34Spain

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