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Studies of Molecular Events in Isolated Nucleolar Chromatin in Response to Chemicals and Ionizing Radiation

  • Ole Frederik Nielsen
  • Bernhard Borkhardt
  • Mahmut Carin
  • Børge F. Jensen
  • Dieter Jentsch
  • Johan C. Leer
  • Ole Westergaard
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 40)

Abstract

Chromatin is an important target for the effect of chemicals and ionizing radiation in living cells. The structural alterations induced lead to disturbance of the genetic expression, i.e. of the biosynthesis of RNA and of protein. One useful approach to explore the molecular background of various observed end-effects is to study the effect of damage on a specific gene which has been isolated in its chromatin form.

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Ole Frederik Nielsen
    • 1
  • Bernhard Borkhardt
    • 1
  • Mahmut Carin
    • 1
  • Børge F. Jensen
    • 1
  • Dieter Jentsch
    • 1
  • Johan C. Leer
    • 1
  • Ole Westergaard
    • 1
  1. 1.Department of Molecular Biology and Plant PhysiologyUniversity of AarhusAarhus CDenmark

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