Studies of Molecular Events in Isolated Nucleolar Chromatin in Response to Chemicals and Ionizing Radiation
Chromatin is an important target for the effect of chemicals and ionizing radiation in living cells. The structural alterations induced lead to disturbance of the genetic expression, i.e. of the biosynthesis of RNA and of protein. One useful approach to explore the molecular background of various observed end-effects is to study the effect of damage on a specific gene which has been isolated in its chromatin form.
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- Hirschberg, E., 1975, Thiaxanthenones: Miracil D and Hycanthone, in “Antibiotics”, Vol. III, Corona, ed., Springer Verlag, BerTinNew York.Google Scholar
- Weinstein, J. B., Chernoff, R., Finkelstein, J., and Hirschberg, E., 1965, Miracil D: An inhibitor of ribonucleic acid synthesis in Bacillus subtilis, Molec. Pharmacol., 1: 297.Google Scholar