Chromosome Aberrations and Sister Chromatid Exchanges in Persons Occupationally Exposed to Mutagens/Carcinogens
It is generally accepted that some 5% of all human cancer results from occupational exposure to carcinogens. An increased incidence of respiratory tract cancer has been reported from nickel refineries in Wales, Russia, Canada and Norway1. Epidemiological studies from a Norwegian nickel refinery2 show that workers exposed to various nickel compounds for more than 3 years have a ratio of observed versus expected respiratory tract cancer of 13.9. Chromosome studies of humans exposed to nickel have not previously been reported.
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