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Induction of Sister Chromatid Exchanges by Non-Mutagenic Carcinogens

  • K. Athanasiou
  • S. A. Kyrtopoulos
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 40)

Abstract

The well known ability of many carcinogens to act as mutagens under suitable conditions constitutes strong evidence that interaction with, and chemical modification of DNA is an essential part of the process whereby such agents bring about neoplastic transformation (Ames, 1979; Hollstein et al., 1979). This view is further supported by the direct detection in many cases of covalent carcinogen-DNA adducts or other types of carcinogen-induced DNA modification (Grover, 1978).

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • K. Athanasiou
    • 1
  • S. A. Kyrtopoulos
    • 1
  1. 1.Biological Research CentreThe National Hellenic Research FoundationAthensGreece

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