Induction of Sister Chromatid Exchanges by Non-Mutagenic Carcinogens

  • K. Athanasiou
  • S. A. Kyrtopoulos
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 40)


The well known ability of many carcinogens to act as mutagens under suitable conditions constitutes strong evidence that interaction with, and chemical modification of DNA is an essential part of the process whereby such agents bring about neoplastic transformation (Ames, 1979; Hollstein et al., 1979). This view is further supported by the direct detection in many cases of covalent carcinogen-DNA adducts or other types of carcinogen-induced DNA modification (Grover, 1978).


DMSO Recombination Chloroform Toluene Adduct 


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  1. Abe, S., and Sasaki, M., 1977, Chromosome aberrations and sister chromatid exchanges in Chinese hamster cells exposed to various chemicals, J. Natl. Canc. Tnst., 58: 1635.Google Scholar
  2. Ames, B.N., 1979, Identifying environmental chemicals causing mutations and cancer, Science, 204: 587.PubMedCrossRefGoogle Scholar
  3. Ashby, J. and Styles, J.A., 1978, Does carcinogenic potency correlate with mutagenic potency in the Ames assay? Nature, 271: 452.PubMedCrossRefGoogle Scholar
  4. Ashby, J., Styles, J.A., Anderson, D., and Paton, D., 1978, Saccharin: an epigenetic carcinogen/mutagen? Food Cosmet. Toxicol., 16: 95.PubMedCrossRefGoogle Scholar
  5. Boyland, E., 1980, History and future of chemical carcinogenesis, Brit. Med. Bull., 36: 5.PubMedGoogle Scholar
  6. Cameron, R., Lee, G., and Farber, E., 1978, Chemical mitogens as effective alternatives to partial hepatectomy in the new model for the sequential analysis of hepatocarcinogenesis, Proc. Am. Assoc. for Canc. Res., 19: 56.Google Scholar
  7. Fornace, A.J., Nagasawa, H., and Little, J.B., 1980, Relationship of DNA repair to chromosome aberrations, sister-chromatid exchanges and survival during liquid-holding recovery in X-irradiated mammalian cells, Mutat. Res., 70: 323.PubMedCrossRefGoogle Scholar
  8. Grover, P.L., 1978, “Carcinogens and DNA”, CRC Press, Boca Raton, FloridaGoogle Scholar
  9. Hollstein, M., McCann, J., Angelosanto, F.A., and Nichols, W.W., 1979, Short-term screening tests for carcinogens and mutagens, Mutat. Res., 65: 133.PubMedGoogle Scholar
  10. Kinsella, A.R., and Radman, M., 1978, Tumour promoter induces sister chromatid exchanges -relevance to mechanisms of carcinogenesis, Proc. Natl. Acad. Sci. U.S.A., 75: 6149.CrossRefGoogle Scholar
  11. McCann, J., Choi, E., Yamasaki, E., and Ames, B.N., 1975, Proc. Natl. Acad. Sci. U.S.A., 72: 5135.PubMedCrossRefGoogle Scholar
  12. Peraino, C., Fry, M.R., Staffeld, E., and Christopher, J.P., 1975, Comparative enhancing effect of phenobarbital, amobarbital, diphenylhydantoin, and dichlorodiphenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumorïgenesis in the rat, Canc. Res., 35: 2884.Google Scholar
  13. Perry, P., and Evans, H.J., 1975, Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange, Nature, 258: 121.PubMedCrossRefGoogle Scholar
  14. Perry, P., and Wolff, S., 1974, New Giemsa method for the differential staining of sister chromatids, Nature, 251: 156.PubMedCrossRefGoogle Scholar
  15. Swenberg, J.A., Petzold, G.L., and Harbach, 1976, In vitro DNA damage/alkaline elution assay for predicting carcinogenic potential, Biochem. Biophys. Res. Commun., 72: 732.PubMedCrossRefGoogle Scholar
  16. Wolff, S., 1977, Sister chromatid exchange, Ann. Rev. Genet., 11: 183.PubMedCrossRefGoogle Scholar
  17. Wolff, S., and Rodin, B., 1978, Saccharin-induced sister chromatid exchanges in chinese hamster and human cells, Science, 200: 543.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • K. Athanasiou
    • 1
  • S. A. Kyrtopoulos
    • 1
  1. 1.Biological Research CentreThe National Hellenic Research FoundationAthensGreece

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