Induction of Sister Chromatid Exchanges by Non-Mutagenic Carcinogens
The well known ability of many carcinogens to act as mutagens under suitable conditions constitutes strong evidence that interaction with, and chemical modification of DNA is an essential part of the process whereby such agents bring about neoplastic transformation (Ames, 1979; Hollstein et al., 1979). This view is further supported by the direct detection in many cases of covalent carcinogen-DNA adducts or other types of carcinogen-induced DNA modification (Grover, 1978).
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- Cameron, R., Lee, G., and Farber, E., 1978, Chemical mitogens as effective alternatives to partial hepatectomy in the new model for the sequential analysis of hepatocarcinogenesis, Proc. Am. Assoc. for Canc. Res., 19: 56.Google Scholar
- Grover, P.L., 1978, “Carcinogens and DNA”, CRC Press, Boca Raton, FloridaGoogle Scholar
- Peraino, C., Fry, M.R., Staffeld, E., and Christopher, J.P., 1975, Comparative enhancing effect of phenobarbital, amobarbital, diphenylhydantoin, and dichlorodiphenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumorïgenesis in the rat, Canc. Res., 35: 2884.Google Scholar