Cell Cycle Patterns of Mutation Induction and Their Relationship to DNA Repair
From the finding that mutation induction by ethylnitrosourea is cell-cycle independent in synchronous Chinese hamster ovary cells and from the observation that these cells do not excise O6-alkylguanine, it is concluded that enhanced mutagenesis at growing points, as observed in bacteria and yeast, is due to a repair system which removes mutagenic lesions at sites other than the DNA growing point, where immediate mutation fixation occurs.
KeywordsMutation Induction Purine Base Mutagenic Lesion Mutation Fixation Cell Cycle Pattern
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