Cell Cycle Patterns of Mutation Induction and Their Relationship to DNA Repair

  • Regine Goth-Goldstein
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 40)


From the finding that mutation induction by ethylnitrosourea is cell-cycle independent in synchronous Chinese hamster ovary cells and from the observation that these cells do not excise O6-alkylguanine, it is concluded that enhanced mutagenesis at growing points, as observed in bacteria and yeast, is due to a repair system which removes mutagenic lesions at sites other than the DNA growing point, where immediate mutation fixation occurs.


Mutation Induction Purine Base Mutagenic Lesion Mutation Fixation Cell Cycle Pattern 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Regine Goth-Goldstein
    • 1
  1. 1.Laboratory of RadiobiologyUniversity of CaliforniaSan FranciscoUSA

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