Involvement of ATP in Repair and Mutagenesis of X-Irradiated Mammalian Cells

  • Françoise Laval
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 40)


In mammalian cells, the existence of an error-prone repair process has been reported after UV-irradiation(1–2). However, in X-irradiated cells, the existence of a similar process is only suggested by the suppression of malignant transformation by protease inhibitors(3). We have previously shown that treatment with an uncoupler of oxidative phosphorylation increased the survival of X-irradiated cells (4).Therefore experiments were designed to determine whether this survival increase was related to the cellular ATP concentration and could be explained by the existence of an error-prone repair system.


Hypoxic Condition Carbonyl Cyanide Survival Increase Methyl Methane Sulfonate Methyl Methane 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Françoise Laval
    • 1
  1. 1.Groupe de Recherches de Radiologie CliniqueInstitut Gustave-RoussyVillejuifFrance

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