Involvement of ATP in Repair and Mutagenesis of X-Irradiated Mammalian Cells
In mammalian cells, the existence of an error-prone repair process has been reported after UV-irradiation(1–2). However, in X-irradiated cells, the existence of a similar process is only suggested by the suppression of malignant transformation by protease inhibitors(3). We have previously shown that treatment with an uncoupler of oxidative phosphorylation increased the survival of X-irradiated cells (4).Therefore experiments were designed to determine whether this survival increase was related to the cellular ATP concentration and could be explained by the existence of an error-prone repair system.
KeywordsHypoxic Condition Carbonyl Cyanide Survival Increase Methyl Methane Sulfonate Methyl Methane
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- 2.Dasgupta U.B., and Summers, W.C.:UV-reactivation of herpes simplex virus is mutagenic and inducible in mammalian cells. Proc. Natl. Acad. Sci., U.S.A., 75, 2 378, 1978.Google Scholar