Chromosomal Radiosensitivity in Fanconi’s Anaemia
Fanconi’s anaemia (FA) is an inherited condition in which congenital abnormalities are associated with bone marrow failure. Along with Ataxia telangiectasia and Bloom’s syndrome, Fanconi’s anaemia is one of the chromosome breakage syndromes displaying spontaneous chromosome instability. Although these diseases are rare the fact that patients carry an elevated risk of developing cancer makes them important and this cancer risk may be related to defective ability to repair certain kinds of damage to their DNA.
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