Ataxia-Telangiectasia: Studies on DNA Repair Synthesis in Fibroblast Strains
DNA repair synthesis was studied in human skin fibroblast strains derived from six patients with ataxia telangiectasia (AT) and four normal donors. The cells were treated with gamma irradiation under aerobic conditions and with the carcinogens methyl methane sulfonate (MMS), N-methyl-N’nitro-N-nitrosoguanidine (MNNG) and mitomycin C (MMC). The patterns of dose response and the variations in “DNA repair capacity” were similar in both the AT and normal cell strains, except in one of the normal strains which showed a significantly reduced dose response towards gamma-irradiation and MMS.
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