Effects of Ultraviolet-Irradiation on DNA Ligase Activity of Human Fibroblasts from Normal and Xeroderma Pigmentosum Donors
Ultraviolet (UV)-irradiation of stationary cultures induces an increase of DNA ligase activity in both normal and complementation group A xeroderma pigmentosum (XP) cells. Extents and doses of induction are cell line-dependent. These inductions can be prevented by the protein synthesis inhibitor cycloheximide, but not by the DNA replication inhibitor fluorodeoxyuridine (FudR).
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