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Effects of Ultraviolet-Irradiation on DNA Ligase Activity of Human Fibroblasts from Normal and Xeroderma Pigmentosum Donors

  • S. Nocentini
  • M. Mezzina
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 40)

Abstract

Ultraviolet (UV)-irradiation of stationary cultures induces an increase of DNA ligase activity in both normal and complementation group A xeroderma pigmentosum (XP) cells. Extents and doses of induction are cell line-dependent. These inductions can be prevented by the protein synthesis inhibitor cycloheximide, but not by the DNA replication inhibitor fluorodeoxyuridine (FudR).

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • S. Nocentini
    • 1
  • M. Mezzina
    • 2
  1. 1.Institut CurieSection de BiologieParis cedex 05France
  2. 2.Institut de Recherches Scientifiques sur le CancerCNRSVilleJuifFrance

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