Effects of Ultraviolet-Irradiation on DNA Ligase Activity of Human Fibroblasts from Normal and Xeroderma Pigmentosum Donors

  • S. Nocentini
  • M. Mezzina
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 40)


Ultraviolet (UV)-irradiation of stationary cultures induces an increase of DNA ligase activity in both normal and complementation group A xeroderma pigmentosum (XP) cells. Extents and doses of induction are cell line-dependent. These inductions can be prevented by the protein synthesis inhibitor cycloheximide, but not by the DNA replication inhibitor fluorodeoxyuridine (FudR).


Xeroderma Pigmentosum Complementation Group Micrococcus Luteus Thymine Dimer Protein Synthesis Inhibitor Cycloheximide 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • S. Nocentini
    • 1
  • M. Mezzina
    • 2
  1. 1.Institut CurieSection de BiologieParis cedex 05France
  2. 2.Institut de Recherches Scientifiques sur le CancerCNRSVilleJuifFrance

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