Protein “X” Synthesis in Mammalian Cells
The unimpeded progress of proliferation and replication should be monitored precisely by each cell. In E. coli, such a monitoring system has indeed been detected. Upon inhibition of proliferation, it generates signals which cause the induction of “protein X” (= recA product) (Inouye and Pardee, 1970; Gudas and Pardee, 1976; McEntee, 1977). This protein then elicits the appearance of “SOS functions” (for reviews see Witkin, 1976; and Devoret, 1978). It seems that some of these SOS functions may also exist in eukaryotic cells, e.g. Weigle reactivation (Sarasin and Hanawalt, 1978; Lytle and Goddard, 1979) and pro-virus induction (Links et al., 1977). We examine here whether mammalian cells respond to an inhibition of replication by induction of new proteins*.
KeywordsLymphoid Cell Line recA Product Primary Skin Fibroblast Histone Synthesis Arrest Replication Fork
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- Mallick, U., Rahmsdorf, H.J., Ponta, H. Coquerelle, T., Eife, R. and Herrlich, P., 1980, Stop of replication induces and represses the-synthesis of specific proteins in mammalian cells. Abstracts, 2nd. Internat. Congr. Cell Biology, Berlin.Google Scholar