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The Use of Direct Photoreversal of UV-Irradiated DNA for the Demonstration of Pyrimidine Dimer-DNA Glycosylase Activity

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Chromosome Damage and Repair

Part of the book series: NATO Advanced Study Institutes Series ((NSSA,volume 40))

Abstract

A two-step enzymatic mechanism for the incision of UV-irradiated DNA at pyrimidine dim ers (PD) by the “UV endonuclease” activity from M. luteus has recently been proposed (1–3). This mechanism is related to the classical base excision repair mode (4), since it consists of the sequential action of a PD-specific DNA glycosylase and an apurinic/apyrimidinic (AP) endonuclease. Such a two-step mechanism was interesting to us for the relevance it might have to our continuing investigations of the repair of UV-irradiated DNA in a variety of biological systems.

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References

  1. Grossman, L., Riazzudin, S., Haseltine, W.A., and Lindan, C. (1979) Cold Spring Harb. Symp. Quant. Biol. 43, 947.

    Article  CAS  PubMed  Google Scholar 

  2. Haseltine, W.A., Gordon, L.K., Lindan, C.P., Grafstrom, R.H., Shaper, N.L., and Grossman, L. (1980) Nature 285, 634.

    Article  CAS  PubMed  Google Scholar 

  3. Grafstrom, R., Shaper, N., Grossman, L., and Haseltine, W.A. (1981) (this volume).

    Google Scholar 

  4. Friedberg, E.C. (this volume).

    Google Scholar 

  5. Radany, E.H., and Friedberg, E.C. (1980) Nature 286, 182.

    Article  CAS  PubMed  Google Scholar 

  6. Friedberg, E.G., Anderson, C.T.M., Bonura, T., Cone, R., Radany, E.H., and Reynolds, R.J. (1980). Prow. Nuc. Acid Res. Mol. Biol. 26, 197.

    Article  Google Scholar 

  7. Setlow, R.B. (1966) Science 153, 379.

    Article  CAS  PubMed  Google Scholar 

  8. Setlow, R.B. (1968) Frog. Nuc. Acid Res. Mol. Biol. 8, 257.

    Article  CAS  Google Scholar 

  9. Rahn, R.O. and Landry, L.C. (1973) Photochem. Photobiol. 18, 29.

    Article  CAS  PubMed  Google Scholar 

  10. Yasuda, S., and Sekiguchi, M. (1970) Proc. Natl. Acad. Sci. (US) 67, 1839.

    Article  CAS  Google Scholar 

  11. Friedberg, E.C., and Lehman, I.R. (1974) Biochem. Biophys. Res. Comm 58, 132.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Laboratory of Experimental Oncology Department of Pathology, Stanford University, Stanford, California, 94305, USA

    Eric H. Radany, Jack D. Love & Errol C. Friedberg

Authors
  1. Eric H. Radany
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  2. Jack D. Love
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  3. Errol C. Friedberg
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Editor information

Editors and Affiliations

  1. Norwegian Defense Research Establishment, Kjeller, Norway

    Erling Seeberg

  2. University of Bergen, Bergen, Norway

    Kjell Kleppe

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© 1981 Plenum Press, New York

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Radany, E.H., Love, J.D., Friedberg, E.C. (1981). The Use of Direct Photoreversal of UV-Irradiated DNA for the Demonstration of Pyrimidine Dimer-DNA Glycosylase Activity. In: Seeberg, E., Kleppe, K. (eds) Chromosome Damage and Repair. NATO Advanced Study Institutes Series, vol 40. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7956-0_12

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  • DOI: https://doi.org/10.1007/978-1-4684-7956-0_12

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-7958-4

  • Online ISBN: 978-1-4684-7956-0

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