A Model System for Studying Nutritional Interventions on Colon Tumor Growth: Effects of Marine Oil
In the U.S. colonic cancer is the second and third leading cause of death in men and women, respectively. While colonic cancer is multifactorial, a growing body of evidence implies that this disease may be preventable to a significant degree. Epidemiologic evidencel,2 indicates that populations consuming diets high in fat are at greater risk for colon cancer than are populations consuming diets low in fat. Concordance for these findings has been obtained in a number of animal models3–6 using a variety of carcinogens for bowel tumor induction, these workers noted that rats fed diets high in fat had a greater incidence and/or greater number of bowel tumors than rats fed diets low in fat. Sakaguchi et al.7 indicated that the type of dietary fat was important in AOM (azoxymethane)-induced colon tumorigenesis with 5% polyunsaturated-fat (PUFA) diets resulting in a higher tumor incidence, tumor number, and greater degree of histologic malignant differentiation, than in rats fed saturated-fat diets. Studies from this lab a few years ago4 and work of Reddy and Maeura8 indicated that dietary PUFA were also more effective in increasing carcinogen-induced bowel tumor yields than saturated fat.
KeywordsMammary Carcinogenesis Bowel Tumor Tumor Growth Assay Pulmonary Colonization Pulmonary Coloni
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