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A Model System for Studying Nutritional Interventions on Colon Tumor Growth: Effects of Marine Oil

  • Selwyn A. Broitman
  • Francis CannizzoJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 322)

Abstract

In the U.S. colonic cancer is the second and third leading cause of death in men and women, respectively. While colonic cancer is multifactorial, a growing body of evidence implies that this disease may be preventable to a significant degree. Epidemiologic evidencel,2 indicates that populations consuming diets high in fat are at greater risk for colon cancer than are populations consuming diets low in fat. Concordance for these findings has been obtained in a number of animal models3–6 using a variety of carcinogens for bowel tumor induction, these workers noted that rats fed diets high in fat had a greater incidence and/or greater number of bowel tumors than rats fed diets low in fat. Sakaguchi et al.7 indicated that the type of dietary fat was important in AOM (azoxymethane)-induced colon tumorigenesis with 5% polyunsaturated-fat (PUFA) diets resulting in a higher tumor incidence, tumor number, and greater degree of histologic malignant differentiation, than in rats fed saturated-fat diets. Studies from this lab a few years ago4 and work of Reddy and Maeura8 indicated that dietary PUFA were also more effective in increasing carcinogen-induced bowel tumor yields than saturated fat.

Keywords

Mammary Carcinogenesis Bowel Tumor Tumor Growth Assay Pulmonary Colonization Pulmonary Coloni 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    K.K. Carroll and H.T. Khor, Dietary fat in relation to tumorigenesis, Prog Biochem Pharmacol. 10: 308 (1975).PubMedGoogle Scholar
  2. 2.
    “Diet, Nutrition and Cancer,” National Academy Press, Washington, DC (1983).Google Scholar
  3. 3.
    B.S. Reddy, K. Wanatabe, and J.H. Weisburger, Effect of a high-fat diet on colon carcinogenesis in F344 rats treated with 1,2 dimethylhydrazine, methylazoxymethanol acetate, or methylnitrosourea, Cancer Res. 37: 4156 (1977).PubMedGoogle Scholar
  4. 4.
    S.A. Broitman, J.J. Vitale, Vavrousek-Jakuba and L.S. Gottleib, Polyunsaturated fat, cholesterol, and large bowel tumorigenesis, Cancer. 40: 2455 (1977).PubMedCrossRefGoogle Scholar
  5. 5.
    N.D. Nigro, D.V. Singh, R.L. Campbell and M. Sook, Effects of diet on intestinal tumor formation by azoxymethane in rats. J Natl Cancer Inst. 54: 439 (1975).PubMedGoogle Scholar
  6. 6.
    B.R. Bansal, E. Rhoads Jr., and S.C. Bansal, Effects of diet on colon carcinogenesis and the immune system in rats treated with 1,2 dimethylhydrazine, Cancer Res. 38: 3293 (1978).PubMedGoogle Scholar
  7. 7.
    M. Sakaguchi, Y. Hiramatsu, H. Takada, M. Yamamura, K. Hioki, K. Saito, and M. Yamamoto, Effect of dietary unsaturated and saturated fats on azoxymethane-induced colon carcinogenesis in rats, Cancer Res. 44: 1472 (1984).PubMedGoogle Scholar
  8. 8.
    B.S. Reddy and Y. Maeura, Tumor promotion by dietary fat in azoxymethane-induced colon carcinogenesis in female F344 rats: Influence of amount and source of dietary fat, J Natl Cancer Inst. 72: 745 (1984).PubMedGoogle Scholar
  9. 9.
    L.M. Braden and K.K. Carroll, Dietary polyunsaturated fat in relation to mammary carcinogenesis in rats, Lipids 21: 285 (1986).PubMedCrossRefGoogle Scholar
  10. 10.
    C. Ip, Fat and essential fatty acid in mammary carcinogenesis, Am J Clin Nutr. 45: 218 (1987).PubMedGoogle Scholar
  11. 11.
    C.W. Welsch, Enhancement of mammary turmorigenesis by dietary fat Review of potential mechanisms, Am J Clin Nutr. 45: 192 (1987).PubMedGoogle Scholar
  12. 12.
    T.H. Corbett, D.P. Griswold Jr., B.J. Roberts, J.C. Peckham, and F.M. Schabel Jr., Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure, Cancer Res. 35: 2434 (1975).PubMedGoogle Scholar
  13. 13.
    Report of the American Institute of Nutrition Ad Hoc Committee on Standards for Nutritional Studies, J Nutr 107: 1340 (1977).Google Scholar
  14. 14.
    P.M. Newbeme, Control of Diets in Laboratory Animal Experimentation, in: “ILAR News” Natl Acad of Sciences, Washington, DC, 21:Al (1978).Google Scholar
  15. 15.
    R.J. Holman, The ratio of trienoic: tetraenoic acids in tissue lipids as a measure of essential fatty acid requirement, J Nutr. 70: 405 (1960).PubMedGoogle Scholar
  16. 16.
    R.J. Holman, in: “Dietary Fat and Cancer,” C. Ip, D.F. Birt, A.E. Rogers and C. Mettlin, eds., Alan R. Liss, Inc., New York, (1986).Google Scholar
  17. 17.
    M.G. Brattain, J. Strobel-Stevens, D. Fine, M. Webb and A.M. Sarrif, Establishment of mouse colonic carcinoma cell lines with different metastatic properties, Cancer Res. 40: 2142 (1980).PubMedGoogle Scholar
  18. 18.
    F. Cannizzo, Jr. and S.A. Broitman, Post promotional effects of dietary marine or safflower oils on large bowel or pulmonary implants of CT-26 in mice, Cancer Res. 49: 4289 (1989).PubMedGoogle Scholar
  19. 19.
    A.P. Kyriazis, A.A. Kyriazia, D.G. Scarpelli, M.S. Rao, and R. Lepera, Human pancreatic adenocarcinoma cell line CAPAN-1 in tissue culture and the nude mouse, Am J Pathol. 106: 250 (1982).PubMedGoogle Scholar
  20. 20.
    H. Wexler, Accurate identification of experimental pulmonary metastasis, J Natl Cancer Inst. 36: 641 (1966).PubMedGoogle Scholar
  21. 21.
    F. Cannizzo Jr., C.C. O’Connor and S.A. Broitman, Subcutaneously implanted CT-26 in Balb/c mice: Effect of size of inoculum and type and level of dietary lipid, Submitted for publication.Google Scholar
  22. 22.
    M.M. King and P.B. McCay, Modulation of tumor incidence and possible mechanisms of inhibition of mammary carcinogenesis by dietary antioxidants, Cancer Res. (Suppl) 43: 2485 (1983).Google Scholar
  23. 23.
    K.K. Carroll and G.J. Hopkins, Dietary polyunsaturated fat versus saturated fat in relation to mammary carcinogenesis, Lipids. 14: 155 (1979).PubMedCrossRefGoogle Scholar
  24. 24.
    G.J. Hopkins, T.G. Kennedy, and K.K. Carroll, Polyunsaturated fatty acids as promoters of mammary carcinogenesis induced in Sprague-Dawley rats by 7,12-dimethylbenz(a)anthracene, J Natl Cancer Inst. 66: 517 (1981).PubMedGoogle Scholar
  25. 25.
    A. Tannebaum, The genesis and growth of tumors. III. Effects of a high-fat diet, Cancer Res. 2: 460 (1942).Google Scholar
  26. 26.
    D. Kritchevsky, M.M. Weber and D.M. Klurfield, Dietary fat versus calorie content in initiation and promotion of 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats, Cancer Res. 44: 3174 (1984).PubMedGoogle Scholar
  27. 27.
    L.A. Cohen, D.O. Thompson, Y. Maeura, and J.H. Weisburger, Influence of dietary medium chain triglycerides on the development of N-methylnitrosourea-induced rat mammary tumors, Cancer Res. 44: 5023 (1984).PubMedGoogle Scholar
  28. 28.
    N.E. Hubbard and K.L. Erickson, Enhancement of metastasis from a transplantable mouse mammary tumor by dietary linoleic acid, Cancer Res. 47: 6174 (1987).Google Scholar
  29. 29.
    W.R. Kidwell and M.E. Monaco, Unsaturated fatty acid requirements for growth and survival of a rat mammary tumor cell line, Cancer Res. 38: 4091 (1978).PubMedGoogle Scholar
  30. 30.
    M.S. Wicha, L.A. Liotta, and W.R. Kidwell, Effects of free fatty acids on the growth of normal and neoplastic rat mammary epithelial cells, Cancer Res. 39: 426 (1979).PubMedGoogle Scholar
  31. 31.
    B. Samuelsson, Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation, Science. 220: 568 (1983).PubMedCrossRefGoogle Scholar
  32. 32.
    R.A. Lewis and K.F. Austen, The biologically active leukotrienes. Biosynthesis, metabolism, receptors, functions and pharmacology, J Clin Invest. 73: 889 (1984).PubMedCrossRefGoogle Scholar
  33. 33.
    G.A. Rao and S. Abraham, Reduced growth rate of transplantable mammary adenocarcinoma in C3H mice fed eicosa-9,8,11,14-tetraynoic acid, J Natl Cancer Inst. 58: 445 (1977).PubMedGoogle Scholar
  34. 34.
    V. Hial, Z. Horakova, F.E. Shaff, and M.A. Beavar, Alteration of tumor growth by aspirin and indomethacin: Studies with two transplantable tumors in the mouse, Eur J Pharm. 37: 367 (1976).CrossRefGoogle Scholar
  35. 35.
    G.M. Kollmorgen, M.M. King, S.D. Kosanke, and C. Do, Influence of dietary fat and indomethacin on the growth of transplantable mammary gland tumors in rats, Cancer Res. 43: 4714 (1983).PubMedGoogle Scholar
  36. 36.
    A.M. Fulton, In vivo effects of indomethacin on the growth of murine mammary tumors, Cancer Res. 44: 2416 (1984).PubMedGoogle Scholar
  37. 37.
    E.A. Carter, R.J. Milholland, W. Shea, and M.M. Ip, Effect of prostaglandin inhibitor indomethacin of 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats fed different levels of fat, Cancer Res. 43: 3559 (1983).PubMedGoogle Scholar
  38. 38.
    J.J. Jurkowski and W.T. Cave Jr., Dietary effects of menhaden oil on the growth and membrane lipid composition of rat mammary tumors, J Natl Cancer Inst. 74: 1145 (1985).PubMedGoogle Scholar
  39. 39.
    H. Gabor and S. Abraham, Effect of dietary menhaden oil on tumor cell loss and the accumulation of mass of a transplantable mammary adenocarcinoma in Balb/c mice, J Natl Cancer Inst. 76: 1223 (1986).PubMedGoogle Scholar
  40. 40.
    R.A. Karmali, J. Marsh, and C. Fuchs, Effect of omega-3 fatty acids on growth of a rat mammary tumor, J Natl Cancer Inst. 73: 457 (1984).PubMedGoogle Scholar
  41. 41.
    G. Poste, J. Doll, T.R. Hart and I.J. Fidler, In vitro selection of murine B16 melanoma variants with enhanced tissue-invasive properities, Cancer Res. 40: 1636, 1980.PubMedGoogle Scholar
  42. 42.
    R.A. Karmali, in: “Dietary Fat and Cancer,” C. Ip, D.F. Birt, A.E. Rogers and C. Mettlin, eds., Alan R. Liss, Inc., New York (1986).Google Scholar
  43. 43.
    I.J. Fidler, Tumor heterogeneity and the biology of cancer invasion and metastasis, Cancer Res. 38: 2651 (1978).PubMedGoogle Scholar
  44. 44.
    M.J. Gonzales, R.A. Schemmel, J.I. Gray, L. Dugan Jr., L.G. Scheffield and C.W. Welsch, Effect of dietary fat growth of MCF-7 and MDA-MB 231 human breast carcinomas in athymic nude mice: Relationship between carcinoma growth and lipid peroxidation levels, Carcinogenesis. 12: 1231 (1991).CrossRefGoogle Scholar
  45. 45.
    C.Y. Yang, W.A. Gonnerman, L. Taylor, R.B. Nimberg and P.R. Polgar, Synthetic human parathyroid hormone fragment stimulated prostagladin EZ synthesis by chick calvariae, Endocrin. 120: 63 (1987).CrossRefGoogle Scholar
  46. 46.
    B.S. Reddy and S. Sugie, Effect of different levels of omega-3 and omega-6 fatty acids on azoxymethane-induced colon carcinogenesis on F344 rats, Cancer Res. 48: 6642 (1988).PubMedGoogle Scholar
  47. 47.
    P.A. Craven, R. Saito and F.R. DeRubertis, Role of local prostaglandin synthesis in the modulation of proliferative activity of rat colonic epithelium, J Clin Invest. 72: 1365 (1983).PubMedCrossRefGoogle Scholar
  48. 48.
    R. Nelson, J.C. Tanure, G. Andrianopoulos, G. Souza and W.E.M. Lands, A comparison of dietary fish oil and corn oil in experimental colorectal carcinogenesis, Nutr Cancer. 11: 215 (1988).PubMedCrossRefGoogle Scholar
  49. 49.
    E.E. Deschner, J.S. Lytle, G. Wong, J.F. Ruperto and H.L. Newmark, The effect of dietary omega-3 fatty acids (fish oil) on azoxymethane-induced focal areas of dysplasia and colon tumor incidence, Cancer 66: 2350 (1990).PubMedCrossRefGoogle Scholar
  50. 50.
    A.H. Tashjian, E.F. Voelkel, P. Goldhaber and L. Levine, Successful treatment of hypercalcemia by indomethacin in mice bearing a prostaglandin-producing fibrosarcoma, Prostaglandins 3: 515 (1973).PubMedCrossRefGoogle Scholar
  51. 51.
    W.T. Cave, Dietary n-3 (omega-3) polyunsaturated fatty acid effects on animal tumorigenesis, FASEB Jour. 5: 2160 (1991).Google Scholar
  52. 52.
    J.E. Kinsella, K. Shane Broughton and J.W. Whelan, Dietary unsaturated fatty acids: Interactions and possible needs in relation to eicosanoid synthesis, J Nutr Biochem. 1: 123 (1990).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1992

Authors and Affiliations

  • Selwyn A. Broitman
    • 1
  • Francis CannizzoJr.
    • 1
  1. 1.Departments of Microbiology and PathologyBoston University School of MedicineBostonUSA

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