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Structure Activity Relationships in Some Juvenile Hormone Analogs

  • C. A. Henrick
  • G. B. Staal
  • J. B. Siddall

Abstract

Although the chemical structures of the three known natural juvenile hormones do provide considerable helpful information to a chemist for the synthesis of active analogs, the almost infinite number of conformations that they can adopt is a severely limiting factor in this. When a juvenile hormone elicits a particular biological effect, one anticipates by analogy with more advanced work in related fields, that the hormone adopts a particular conformation during the process of binding to a specific receptor protein. The question of what is the particular shape of a juvenile hormone in its active form is perhaps impossible to answer but is nonetheless important to an understanding of hormone action. Although we do not have the luxury of the relatively rigid tetracyclic molecules of the mammalian sex hormones, some insights may be gained by examination of the biological activity of closely related hormone analogs, provided that suitable bioassay systems are used. We wish to present some of our results from a detailed study of structure-activity relationships within a group of potent juvenile hormone analogs, in order to gain some insights into the likely conformations of the active forms of the juvenile hormones. In so doing we recognize the limitations to the amount of conformational information derivable from whole animal bioassay.

Keywords

Structure Activity Relationship Juvenile Hormone Hormone Analog Natural Hormone Cyclic Ketone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • C. A. Henrick
    • 1
  • G. B. Staal
    • 1
  • J. B. Siddall
    • 1
  1. 1.Zoecon Research LaboratoriesPalo AltoUSA

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