Leukotrienes in the Lung and Cardiovascular System

  • Priscilla J. Piper
  • Marwa N. Samhoun
  • Dolores M. Conroy
  • H. B. Yaacob
  • N. C. Barnes
  • Jane M. Evans
  • J. F. Costello
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 177)


The formation of leukotrienes (LTs) from arachidonic acid derived from phospholipids of the cell membrane is initially catalysed by 5-lipoxygenasel. Metabolism of the unstable epoxide LTA4 leads to the formation of LTB4 and the cysteinyl-containing LTs C4, D4 and E4. All these LTs have potent, although different, biological activities. LTB4 is a powerful chemotactic agent for leukocytes whereas LTs C4, D4 and E4 have potent smooth muscle stimulating actions and account for the biological activity of the allergic mediator previously known as slow-reacting substance of anaphylaxis (SRS-A)2. Leukotriene B4 has pro-inflammatory actions but little smooth muscle stimulating activity of its own whereas cysteinyl-containing LTs have potent actions in the cardiovascular system and in the airways in vitro and in vivo (see3,4).


Airway Smooth Muscle Coronary Perfusion Pressure Glyceryl Ether Calcium Ionophore A23187 Cardiac Anaphylaxis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Priscilla J. Piper
    • 1
  • Marwa N. Samhoun
    • 1
  • Dolores M. Conroy
    • 1
  • H. B. Yaacob
    • 1
  • N. C. Barnes
    • 2
  • Jane M. Evans
    • 2
  • J. F. Costello
    • 2
  1. 1.Department of PharmacologyRoyal College of Surgeons of EnglandLondonUK
  2. 2.Department of Thoracic MedicineKings College School of Medicine and DentistryLondon SE5UK

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