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Prostanoids and Drugs pp 195–219Cite as

Inhibitors of Leukotriene Action: Potential Use in Asthma, Inflammatory Bowel Disease, and Cutaneous Inflammation

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Part of the book series: NATO ASI Series ((NSSA,volume 177))

Abstract

Research carried out in numerous laboratories has led to the hypothesis that metabolites of the ∆5-lipoxygenase (5∆-L0) pathway (e.g., leukotrienes and 5-HETE) may play an important role in mediating a number of inflammatory diseases including asthma, inflammatory bowel disease, and diseases associated with cutaneous inflammation. The purpose of this chapter is to briefly review the rationale supporting this hypothesis and to present the results of some experimental studies with promising ∆5-L0 inhibitors and leukotriene antagonists which would support the clinical evaluation of these types of drugs in the three disease states.

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  1. Hoffmann-La Roche, Inc., 340 Kingsland Street, Nutley, NJ, 07110, USA

    A. F. Welton, P. C. Will, D. W. Morgan, H. Crowley, M. O’Donnell, J. Hurley & S. Shapiro

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  5. M. O’Donnell
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Editors and Affiliations

  1. Karolinska Institute, Stockholm, Sweden

    B. Samuelsson

  2. University of Milan, Milan, Italy

    F. Berti

  3. University of Parma, Parma, Italy

    G. C. Folco

  4. University of Verona, Verona, Italy

    G. P. Velo

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Welton, A.F. et al. (1989). Inhibitors of Leukotriene Action: Potential Use in Asthma, Inflammatory Bowel Disease, and Cutaneous Inflammation. In: Samuelsson, B., Berti, F., Folco, G.C., Velo, G.P. (eds) Prostanoids and Drugs. NATO ASI Series, vol 177. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7938-6_21

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