Modulation of the Inflammatory Potential of the 5-Lipoxygenase Pathway by Alternative Fatty Acids and Cytokines

  • Robert A. Lewis
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 177)


The inflammatory products of the 5-lipoxygenase pathway are considered to be locally-acting mediators, as compared to hormonal factors which can evoke their effects at great distances from the cell of origin. This is presumed to be correct because, despite the nanomolar potencies of several of these fatty acid metabolites for eliciting their effects, the quantities generated pathophysiologically are likely to be quite limited and the rate of metabolic inactivation in the circulation, significant. However, it is likewise clear that two classes of molecules that are more broadly bioavailable in the circulation, namely N-3 fatty acids provided in the diet by the oils of marine fish and certain cytokines, can have profound effects upon the generation of the 5-lipoxygenase products and certain of their elicited biological responses. Examples of such circulating regulators presetting the capacities for local mediator generation and response are the subject of this review.


Arachidonic Acid Epoxide Hydrolase Rheumatoid Arthritic Calcium Ionophore A23187 Human Eosinophil 


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Robert A. Lewis
    • 1
  1. 1.Syntex ResearchSyntex CorporationPalo AltoUSA

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