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Aspects of Eicosanoids in Inflammation

  • Per Hedqvist
  • Sven-Erik Dahlén
  • Johan Raud
  • Lennart Lindbom
  • Åsa Thuresson-Klein
  • K. C. Nicolaou
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 177)

Abstract

The microvascular system has a key role in host defence and expression of the inflammatory process which is indispensible for the elimination of foreign and noxious agents. Regardless of the nature of the initiating stimulus, the sequence of microvascular events in early inflammation is with few exceptions characterized by the following partly overlapping reactions; (i) changes in arteriolar diameters and blood flow, (ii) increased venular permeability promoting macromolecular leakage and formation of tissue edema, and (iii) diapedesis and migration of leukocytes into the area of injury. It is also becoming increasingly clear that the waxing and waning of the inflammatory process, rather than being a static phenomenon, is the result of a continuous interplay between mediators, modulators, and feed back mechanisms.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Per Hedqvist
    • 1
  • Sven-Erik Dahlén
    • 1
  • Johan Raud
    • 1
  • Lennart Lindbom
    • 1
  • Åsa Thuresson-Klein
    • 2
    • 3
  • K. C. Nicolaou
    • 4
  1. 1.Department of Physiology and the Institute of Environmental MedicineKarolinska InstitutetStockholmSweden
  2. 2.Department of PharmacologyUniversity of Mississippi Medical CenterJacksonUSA
  3. 3.Department of ToxicologyUniversity of Mississippi Medical CenterUSA
  4. 4.Department of Organic ChemistryUniversity of PennsylvaniaPhiladelphiaUSA

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