Gastric Mucosal Damage by Nonsteroidal Anti-Inflammatory Drugs

  • A. Bennett
  • I. A. Tavares
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 177)


Gastric mucosal damage caused by nonsteroidal anti-inflammatory drugs (NSAIDs) is a major clinical problem, and it is therefore important to understand the mechanisms involved. There are numerous complexities, including the fact that NSAIDs may have several actions besides inhibition of cyclo-oxygenase. However, even considering only the latter enzyme there will be inhibition of thromboxane synthesis as well as of the various PGs (some of which may have different actions); there may also be some diversion of substrate metabolism into leukotrienes and other fatty acid derivatives, although this is controversial.


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • A. Bennett
    • 1
  • I. A. Tavares
    • 1
  1. 1.Department of Surgery King’s College School of Medicine and DentistryThe Rayne InstituteLondonUK

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