Gastric Mucosal Damage by Nonsteroidal Anti-Inflammatory Drugs
Gastric mucosal damage caused by nonsteroidal anti-inflammatory drugs (NSAIDs) is a major clinical problem, and it is therefore important to understand the mechanisms involved. There are numerous complexities, including the fact that NSAIDs may have several actions besides inhibition of cyclo-oxygenase. However, even considering only the latter enzyme there will be inhibition of thromboxane synthesis as well as of the various PGs (some of which may have different actions); there may also be some diversion of substrate metabolism into leukotrienes and other fatty acid derivatives, although this is controversial.
KeywordsArachidonic Acid Gastric Mucosa Gastric Mucosal Damage Major Clinical Problem Human Gastric Mucosa
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