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Role of Leukotrienes in Experimental Gastric Ulceration

  • B. M. Peskar
  • E. Bacha
  • P. Nowak
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 177)

Abstract

Gastric mucosal damage induced by topical irritants such as ethanol, strong acid or strong base are preceded by severe disturbances of the gastric mucosal microcirculation resulting in a decrease in mucosal blood flow, vascular stasis, marked engorgement of microvessels and leakage of plasma proteins and blood cells.1,2 Gastroprotective compounds such as prostaglandins (PG) prevent the microcirculatory changes caused by the irritants.1.2 The cysteinyl leukotrienes (LT) LTC4 and LTD4 infused into the arterial supply of the rat stomach cause a rapid and marked decrease in vascular flow rate.3,4 Furthermore, LTC4, but not LTD4, has been found to induce sluggish blood flow and stasis in the rat gastric submucosal microcirculation closely resembling the effects of topical irritants.5 Finally, both LTC4and LTD4, although not ulcerogenic themselves, potentiate the noxious effects of gastric irritants.6,7

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • B. M. Peskar
    • 1
  • E. Bacha
    • 1
  • P. Nowak
    • 1
  1. 1.Department of Experimental Clinical MedicineRuhr-University of BochumBochumGermany

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