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Renal and Platelet Eicosanoids in Chronic Glomerular Disease

  • Carlo Patrono
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 177)

Abstract

Eicosanoid is the generic term which refers to lipoxygenase and cyclooxygenase products of arachidonate metabolism. Prostaglandins (PG) and the other eicosanoids are autacoids which do not have a circulating, endocrine function but rather act in a paracrine or autocrine manner affecting cells close to or at the site of PG synthesis1. Nonsteroidal anti-inflammatory drugs (NSAD) inhibit either irreversibly (aspirin) or reversibly the cyclooxygenase enzyme which converts arachidonate to the PG-endoperoxides. Presently, no similar inhibitory agents are clinically available which inhibit the lipoxygenase enzymes converting arachidonate to leukotrienes and monohydroxy fatty acids. Although glucocorticoids can limit substrate availability through the induction of a recently characterized phospholipase A2-inhibitory protein named lipocortin, their in vivo effects on endogenous PG production are rather inconsistent.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Carlo Patrono
    • 1
  1. 1.Department of PharmacologyCatholic University School of MedicineRomeItaly

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