Cardioprotective Effects of Prostacyclin Analogues

  • Fiona M. McDonald
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 177)


In recent years, a considerable amount of evidence has accumulated suggesting that prostacyclin and prostacyclin analogues show cardioprotective activity in a number of different models of myocardial injury. Cardioprotective effects may be manifest in a variety of ways, including biochemical (e.g. conservation/improved recovery of mitochondrial oxidative function), morphological (preservation of myocyte ultrastructure), functional (enhancement of local or global mechanical performance) and electrical (anti-arrhythmic) protection. This has resulted in a multitude of parameters being used to assess both the extent of myocardial injury and the degree of myocardial protection. Tables 1 and 2 summarise some of the situations in which effects of prostacyclin or prostacyclin analogues have been seen, and interpreted as cardioprotection.


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Fiona M. McDonald
    • 1
  1. 1.Research Laboratories of Schering AG, Berlin (West) and BergkamenBerlin 65 (West)Germany

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