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Adenovirus DNA Replication

  • Thomas J. KellyJr.
Part of the The Viruses book series (VIRS)

Abstract

As documented throughout this book, the adenoviruses have proved to be useful models for probing the basic mechanisms of macromolecular synthesis in eukaryotic cells. Much of the work on adenovirus DNA replication has been motivated by the idea that analysis of the replication of simple viral chromosomes may provide insights useful for understanding the complex mechanisms involved in the replication of eukaryotic chromosomes. Progress in this area has been rapid in recent years. Many of the general features of the adenovirus DNA replication pathway are now reasonably well understood from analysis of viral DNA synthesis in vivo. In addition, a cell-free replication system dependent on exogenous adenovirus DNA templates has been developed. This system has provided a means to explore the molecular mechanisms involved in initiation and chain elongation and to purify and characterize replication proteins. This chapter summarizes the available information on adenovirus DNA replication with particular emphasis on current developments. Additional information may be found in several recent reviews of the subject (Winnacker, 1978; Flint and Broker, 1980; Kelly, 1982; Challberg and Kelly, 1982).

Keywords

Cold Spring Harbor Replication Complex Adenovirus Type Human Adenovirus Replicative Intermediate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Thomas J. KellyJr.
    • 1
  1. 1.Department of Molecular Biology and GeneticsThe Johns Hopkins University School of MedicineBaltimoreUSA

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