The Genetic System

  • C. S. H. Young
  • T. Shenk
  • Harold S. Ginsberg
Part of the The Viruses book series (VIRS)


The use of genetics to study the interactions of adenoviruses with permissive and nonpermissive host cells has had two primary goals. One is to enumerate the genes and the functions encoded by them, a task that in recent years has depended more on the ability to map specific messenger RNAs (mRNAs) to particular regions of the genome than on classic genetic analysis. The other is to use mutants of various kinds in functional studies to determine the role of specific genes in such processes as the control of RNA transcription, DNA replication, host-cell transformation, and viral assembly. In these functional roles, adenovirus mutants have been of great practical benefit, as a reading of the following chapters in this volume will show. With the development of in vitro systems to study specific processes, mutants have been and will continue to be of great value in dissecting the steps involved and, importantly, in confirming the faithfulness of the reconstituted systems to the events detected in vivo.


Adenovirus Recombination Adenovirus Type Human Adenovirus Helper Virus Adenovirus Gene 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • C. S. H. Young
    • 1
  • T. Shenk
    • 2
  • Harold S. Ginsberg
    • 1
  1. 1.Department of MicrobiologyCollege of Physicians and Surgeons of Columbia UniversityNew YorkUSA
  2. 2.Department of MicrobiologyState University of New York at Stony BrookStony BrookUSA

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