On the Detectability of Low Velocity High Mass Ions in Matrix Assisted Laser Desorption TOF-MS

  • Raimund Kaufmann
  • Bernhard Spengler
  • Dieter Kirsch
Part of the NATO ASI Series book series (NSSB, volume 269)


Within the last two years matrix assisted laser desorption mass spectrometry of high mass organic molecules has rapidly evolved. The range of useful matrices has been widely enlarged [1] and the demonstrated detectability now covers proteins (up to several hundred kDa), polynucleotides including large DNA fragments (see paper of P. Williams, this volume), glycoproteins and polysaccharides. The notion that this technique is restricted to UV-lasers has recently become historical after Hillenkamp et al. [2] have demonstrated infrared lasers (Er:YAG, CO2) to be as effective in high mass ion production as UV-lasers.


Secondary Particle Secondary Electron Emission Transmitted Primary Surface Induce Dissociation Insulin Monomer 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Raimund Kaufmann
    • 1
  • Bernhard Spengler
    • 1
  • Dieter Kirsch
    • 1
  1. 1.Institut für LasermedizinUniversität DüsseldorfDüsseldorfGermany

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